Lack of effect of granulocyte-macrophage colony-stimulating factor on secretion of interferon-tau, other proteins, and prostaglandin E2 by the bovine and ovine conceptus.

Domestic Animal Endocrinology
A A de MoraesP J Hansen

Abstract

Three experiments tested the effects of recombinant bovine granulocyte-macrophage colony-stimulating factor (rbGM-CSF) on the preimplantation bovine and ovine conceptus. There was no effect of rbGM-CSF on the secretion of total radiolabeled protein in conditioned medium, immunoreactive interferon-tau (IFN tau), antiviral activity, or prostaglandin E2 from Day 16-18 bovine conceptuses cultured for 24 hr with, [3H]leucine and +/- 10 ng/ml rbGM-CSF. Similarly, there was no effect of 1 ng/ml rbGM-CSF on the secretion of total radiolabeled protein. IFN tau, or antiviral activity from Day 17 ovine conceptuses. There was also no beneficial effect of 1 or 10 ng/ml rbGM-CSF on the presence of immunoreactive IFN tau in conditioned medium from in vitro-produced bovine blastocysts at Day 7-8 after fertilization. Results indicate that IFN tau secretion from bovine and ovine conceptuses are unresponsive to rbGM-CSF at the concentrations tested.

References

Sep 1, 1992·Biology of Reproduction·J J Hernandez-LedezmaR M Roberts
Aug 1, 1990·Biology of Reproduction·C E FarinR M Roberts
Dec 1, 1988·The Journal of Experimental Zoology·J R MalayerW C Buhi
Apr 29, 1988·Biochemical and Biophysical Research Communications·C H PontzerH M Johnson
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Jan 1, 1995·Reproduction, Fertility, and Development·J A DavidsonP J Hansen

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Citations

Nov 7, 2012·BMC Developmental Biology·Manabu OzawaPeter J Hansen
Jun 24, 2006·American Journal of Reproductive Immunology : AJRI·Donna D MichaelAlan D Ealy
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Alan D EalyLydia K Wooldridge

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