Lack of effect of HPA axis hyperactivity on hormonal responses to d-fenfluramine in major depressed patients: implications for pathogenesis of suicidal behaviour

Psychoneuroendocrinology
F DuvalJ P Macher

Abstract

There is evidence for inhibitory effects of adrenocorticosteroids on serotonergic (5-HT) activity. However, in depression the relationship between altered cortisol levels and brain 5-HT function remains to be clarified. The aim of this study was to investigate whether hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is associated with 5-HT dysfunction in depressed patients, especially in those with suicidal behaviour. Cortisol levels following the dexamethasone suppression test (DST, 1 mg PO) and prolactin, corticotropin and cortisol responses to the d-fenfluramine test (d-FEN, 45 mg PO) - a specific 5-HT releaser/uptake inhibitor - were measured in 71 drug-free DSM-IV major depressed inpatients (40 with a history of suicide attempt, 31 without) and 34 hospitalized healthy control subjects. Depressed patients showed higher post-DST cortisol levels but similar responses to d-FEN compared with control subjects. Hormonal responses to d-FEN were not correlated with cortisol levels (basal or post-DST). Among the depressed patients, DST suppressors and DST nonsuppressors exhibited no significant difference in endocrine responses to d-FEN. However, patients with a history of suicide attempt, when compared with patients without ...Continue Reading

References

Sep 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Stahl
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·M MaesJ Raus
May 1, 1990·Journal of Affective Disorders·P Mitchell, G Smythe
Feb 1, 1990·Acta Psychiatrica Scandinavica·W H NormanJ C Overholser
Mar 1, 1989·Acta Psychiatrica Scandinavica·A SchmidtkeH Beckmann
Oct 1, 1988·Biological Psychiatry·J H Meador-WoodruffR F Haskett
Apr 1, 1986·Psychiatry Research·R P BrownJ J Mann
Dec 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·D M ShawE G Eccleston
Mar 1, 1984·The Journal of Clinical Endocrinology and Metabolism·D A Lewis, B M Sherman
Apr 1, 1995·Psychopharmacology·S B Park, P J Cowen
Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Maes
Mar 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·T G Dinan
Feb 1, 1994·Journal of Affective Disorders·G M GoodwinJ Bancroft
Jan 1, 1995·Psychoneuroendocrinology·M C MokraniJ P Macher
May 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A J CleareV O'Keane
Dec 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E F CoccaroR L Hauger
Jan 1, 1996·Journal of Basic and Clinical Physiology and Pharmacology·T G Dinan, L V Scott
Jan 1, 1997·Psychoneuroendocrinology·M C MokraniJ P Macher
Nov 5, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L H PriceG R Heninger
Jan 14, 1998·Nature Medicine·J J Mann
Aug 15, 1998·Psychiatry Research·R J KavoussiE F Coccaro

❮ Previous
Next ❯

Citations

Jul 31, 2012·Journal of Affective Disorders·Alexander McGirrGustavo Turecki
Apr 5, 2003·Physiology & Behavior·Thomas CampbellKelly Lambert
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jolanta Rajewska, Janusz K Rybakowski
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John G KeilpJ John Mann
Feb 16, 2005·Annual Review of Psychology·Thomas E JoinerLaRicka R Wingate
Aug 27, 2013·Experimental Brain Research·Vasileios BoulougourisGiuseppe Di Giovanni
May 20, 2008·Journal of Affective Disorders·Leandro F Malloy-DinizHumberto Corrêa
Sep 28, 2014·Journal of Affective Disorders·Lucas da Silva CostaModesto Leite Rolim Neto
Dec 14, 2011·Journal of Affective Disorders·Masoud KamaliMelvin G McInnis
Sep 6, 2005·Biological Psychiatry·William PitchotMarc Ansseau
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M A OquendoJ John Mann
Jun 22, 2017·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Sangha Kim, Kyoung-Uk Lee
Nov 30, 2018·The International Journal of Neuroscience·Verónica TrujilloMarta Magdalena Suárez
Feb 5, 2010·Psychoneuroendocrinology·Fabrice DuvalSaïd Fattah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
J H Williams
Canadian Journal of Physiology and Pharmacology
Alessio SulloNicola Maffulli
© 2021 Meta ULC. All rights reserved