Lack of effect of intranigral transplants of a GABAergic cell line on absence seizures

Epilepsy & Behavior : E&B
Claudia G CastilloMagda Giordano

Abstract

The substantia nigra pars reticulata (SNpr) is involved in controlling a variety of seizure phenomena. Intranigral transplants of GABAergic cells have been shown to decrease the severity of already established epileptic seizures, but the effects observed have been short-lived. This study evaluated the ability of intranigral transplants of GABA-producing cells to reduce spontaneous absence seizures in a genetic animal model for periods up to 3 months after transplantation. Intranigral transplants did not induce any behavioral deficits in the animals, and they did not form tumors; however, the transplants failed to decrease absence seizures in the genetic model. The assumed increase in intranigral levels of GABA after the transplants may be insufficient to counteract all the factors involved in generating the absence seizures; in this animal model, it may be necessary to further decrease nigral activity by implanting GABAergic cells in another area. These results bear down on the fact that cell transplants need to be tailored for each type of convulsive disorder in terms of the type of cells delivered and the location of the transplants.

References

Jul 1, 1992·Epilepsy Research·A M CoenenE L van Luijtelaar
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Dec 25, 2003·Epilepsia·Kerry W Thompson, Lucie M Suchomelova
May 27, 2006·Neuroscience and Biobehavioral Reviews·Gilles van Luijtelaar, Evgenia Sitnikova
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeanne Tamar PazStéphane Charpier
Jun 24, 2008·Behavioural Brain Research·Claudia G CastilloMagda Giordano

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Citations

Oct 12, 2010·Epilepsy & Behavior : E&B·Ahmad Ghanizadeh
Jun 25, 2010·Cell Transplantation·Jana Mejía-ToiberMagda Giordano
Sep 22, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zuleyha ErisginYuksel Terzi

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