PMID: 9447867Feb 3, 1998Paper

Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain

Anesthesiology
P K Zahn, T J Brennan

Abstract

Evidence from experiments by others indicates an important role for excitatory amino acids activating spinal n-methyl-d-aspartate (NMDA) receptors in models of persistent pain. The purpose of this study was to examine the effect of intrathecal (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (MK-801), a noncompetitive NMDA receptor antagonist, 2-amino-5-phosphonovaleric acid (AP5), a competitive NMDA receptor antagonist, and N-G-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, on pain behaviors in a rat model of postoperative pain. Rats with intrathecal catheters were anesthetized and underwent a plantar incision. Withdrawal threshold to punctate stimulation applied adjacent to the wound, response frequency to application of a nonpunctate stimulus applied directly to the wound, and nonevoked pain behaviors were measured before and after intrathecal administration of MK-801 or AP5. The effect of intrathecal L-NAME on mechanical hyperalgesia was also examined. Mechanical hyperalgesia increased and was persistent after plantar incision and was not decreased by intrathecal administration of 4, 14, or 40 nmol MK-801 or 10 nmol AP5. Only the greatest dose of AP5, 30 nmol, caused a small decre...Continue Reading

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Citations

May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shiro KoizukaFumio Goto
May 21, 2008·Der Schmerz·E M Pogatzki-Zahn, P K Zahn
Oct 31, 2009·Molecular Neurobiology·Max Larsson
Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Sep 16, 2000·Journal of Pain and Symptom Management·G BennettT Yaksh
Jun 15, 2001·ILAR Journal·Timothy J. Brennan
Oct 10, 2002·Regional Anesthesia and Pain Medicine·Peter K ZahnTimothy J Brennan
Mar 29, 2000·Anesthesia and Analgesia·J S KroinA D Ivankovich
Sep 23, 2008·Anesthesia and Analgesia·Lucinda A GrandeGregory W Terman
Dec 23, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yen-Jing ZengYeong-Ray Wen
Mar 2, 2006·Anesthesiology·Douglas G RirieJames C Eisenach
Nov 24, 2006·Anesthesiology·Ratan K BanikTimothy J Brennan
Sep 4, 2016·Brazilian Journal of Anesthesiology·Ulku EmikCengiz Bekir Demirel
Jul 11, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Daniel F MartinsAdair R S Santos
Aug 14, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Joon-Ho LeeHee-Cheol Jin
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Esther M Pogatzki-ZahnTimothy J Brennan
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Asokumar Buvanendran, Jeffrey S Kroin
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Marc F De Kock, Patricia M Lavand'homme
Nov 1, 2006·The Journal of Pain : Official Journal of the American Pain Society·Hideaki ObataMichelle Vincler
Apr 18, 2003·Acta Anaesthesiologica Scandinavica·M ElhakimA Khattab
Nov 2, 2006·Journal of Neurochemistry·Eryn L WerryMax R Bennett
Aug 10, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Sinyoung KangTimothy J Brennan

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