Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide

British Journal of Clinical Pharmacology
D HartmannW K Waldhäusl

Abstract

1. In a single-blind, placebo controlled study the influence of tenoxicam on responses of glucose, insulin and C-peptide to oral doses of glucose and glibenclamide was examined in 16 healthy male volunteers. 2. The subjects received once daily doses of 2.5 mg glibenclamide for 12 days. From day 5 through 12 eight subjects received concomitantly 20 mg tenoxicam once daily and the remaining eight subjects received placebo. 3. On days 1, 4, 5 and 12 glibenclamide was taken with 75 g glucose and blood glucose, serum insulin and C-peptide were measured over 5 h. Plasma levels of glibenclamide and tenoxicam (where appropriate) were followed over 10 h. 4. Characteristic parameters of blood glucose and insulin and C-peptide responses did not change significantly with time (day) and there was no difference between both treatment groups. 5. Baseline insulin increased from 11.7 mu l-1 on day 1 to 15.6 mu l-1 on day 4 (P = 0.009), likewise baseline C-peptide increased from 478 pmol l-1 to 530 pmol l-1 (P = 0.05), but there was no further change in the subsequent treatment period. 6. The AUC of the glibenclamide plasma concentration-time curve did not show changes with time or differences between treatment groups. The mean (s.d.) oral clear...Continue Reading

References

Dec 27, 1979·The New England Journal of Medicine·R P Robertson, S A Metz
Dec 2, 1988·The Medical Letter on Drugs and Therapeutics
Nov 28, 1986·Journal of Chromatography·H EmilssonI Christenson
Feb 1, 1985·British Journal of Clinical Pharmacology·K StoeckelU Hennes
Jan 10, 1986·Journal of Chromatography·P HeizmannK Zinapold
Jan 1, 1985·Reviews on Drug Metabolism and Drug Interactions·P F D'Arcy, J C McElnay
Jul 1, 1983·Clinical Pharmacokinetics·R K VerbeeckG R Loewen
Jul 1, 1984·Drugs·A C Asmal, A Marble
Oct 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K P RatzmannB Schulz
Jul 1, 1982·British Journal of Clinical Pharmacology·P J MorrisonV A John
Jun 1, 1980·The Journal of Clinical Investigation·O G KoltermanJ M Olefsky
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·W P Newman, R G Brodows
Mar 1, 1981·British Journal of Clinical Pharmacology·B WhitingD S Robins

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