Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model

Pharmacology, Biochemistry, and Behavior
Mark WallaceGery Schulteis

Abstract

Preclinical studies have emphasized that persistent small afferent input will induce a state of central facilitation, which can be regulated by systemically administered sodium channel blockers. We have extended these preclinical studies to the human volunteers by examining the effects of lamotrigine and 4030W92, two structurally related voltage-sensitive sodium channel antagonists, on acute sensory thresholds and facilitated processing induced by intradermal capsaicin. Fifteen healthy subjects received 4030W92, lamotrigine, and placebo in a randomized order using double-blinded crossover design methodology in three sessions each separated by a 7-day washout period. In each session, baseline neurosensory testing was performed on the volar aspect of the subject's left forearm. Subjects were then dosed with either lamotrigine (300 mg), 4030W92 (100 mg), or placebo, followed 2 h later by capsaicin (100 microg) injected intradermally on the volar aspect of the left forearm. Pain scores, blood pressure, heart rate, and respiratory rate were measured at the time of injection and every 5 min for 15 min. Fifteen minutes after the capsaicin injection, the hyperalgesic area was determined by von Frey hair, stroking, and heat; the flare r...Continue Reading

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Citations

Jun 2, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ian Gilron
Mar 30, 2011·Molecular Pain·Ruth RuscheweyhJürgen Sandkühler
Nov 1, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mark S WallaceJared Schettler
Mar 19, 2013·Brain, Behavior, and Immunity·Mark R HutchinsonPaul Rolan
Sep 11, 2009·British Journal of Clinical Pharmacology·Camilla StaahlAsbjørn Mohr Drewes
Mar 5, 2011·British Journal of Pharmacology·Odd-Geir Berge
Jul 12, 2011·British Journal of Clinical Pharmacology·Verna AykanatPaul Rolan
Feb 12, 2015·Clinical Pharmacology and Therapeutics·S M HelfertR Baron
May 21, 2016·British Journal of Clinical Pharmacology·Guido van AmerongenJustin L Hay
Sep 21, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Graham C ScanlonGery Schulteis
Jun 23, 2012·Pharmacological Reviews·Anne Estrup OlesenAsbjørn Mohr Drewes
Dec 17, 2010·Expert Review of Neurotherapeutics·Mark Wallace, Marco Pappagallo
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea

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