PMID: 9536920Apr 16, 1998Paper

Lack of effect of vitamin E on L-arginine-responsive endothelial dysfunction in patients with mild hypercholesterolaemia and coronary artery disease

Clinical Science
P J ChowienczykJ M Ritter

Abstract

1. Dietary supplementation with vitamin E reduces ischaemic events in patients with established coronary artery disease and improves endothelial function in cholesterol-fed rabbits. We examined whether such dietary supplementation with vitamin E improves endothelial function in patients with mild hypercholesterolaemia and coronary artery disease. 2. Twenty patients (total cholesterol 6.8 +/- 1.1 mmol/l, mean +/- SD) with angiographically documented coronary artery disease were randomly allocated to receive placebo (n = 10) or vitamin E, 400 i.u. daily, (n = 10) for 8 weeks. Endothelium-dependent and independent vasodilatation within forearm vasculature was assessed by brachial artery infusion of acetylcholine (co-infused with saline vehicle and L-arginine) and nitroprusside before and after supplementation. 3. Plasma concentrations of vitamin E increased from 32.9 +/- 3.8 to 69.1 +/- 11.8 mumol/l (means +/- SE) in the vitamin E-supplemented group (P < 0.01) but did not change significantly in the placebo group. Lipid profiles remained similar before and after supplementation in both groups. Forearm blood flow responses to acetylcholine (7.5 and 15 micrograms/min) and nitroprusside (3 and 10 micrograms/min) were similar before a...Continue Reading

Citations

Jun 30, 1998·Current Opinion in Lipidology·I B Wilkinson, J R Cockcroft
Jan 29, 2002·Journal of Cardiovascular Pharmacology·L E SpiekerG Noll
Mar 10, 2004·The British Journal of Nutrition·Peter SandersonJoseph A Vita
Jul 9, 2002·Diabetes, Obesity & Metabolism·U Bayraktutan
Mar 9, 2005·Annals of the New York Academy of Sciences·Regine HellerErnst R Werner
Aug 19, 2003·British Journal of Pharmacology·Andrew MacKenzie, Roger M Wadsworth
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Iratxe EskurzaDouglas R Seals
Sep 17, 2004·Endothelium : Journal of Endothelial Cell Research·Hisakazu Ogita, James Liao
Jul 18, 2000·Journal of the American College of Cardiology·R A Skyrme-JonesI T Meredith
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sevgi Yardim-AkaydinBolkan Simşek
Nov 30, 2005·Atherosclerosis·A C KalioraH Schmidt

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