Lack of effects of atrazine on estrogen-responsive organs and circulating hormone concentrations in sexually immature female Japanese quail (Coturnix coturnix japonica)

Chemosphere
K W WilhelmsC G Scanes

Abstract

The widely used herbicide, atrazine, has been reported to exhibit reproductive toxicity in rats and amphibians. The present studies investigate toxicity of atrazine in Japanese quail and its ability to influence reproduction in sexually immature females. Atrazine was administered in the diet at concentrations from 0.001 to 1000 ppm (approximately 109 mg kg-1 per day) or systemically via daily subcutaneous injections (1 and 10 mg kg-1) or Silastic implants. Atrazine did not cause overt toxicity in sexually immature female quail (no effects on change in body weight, feed intake, mortality or on circulating concentrations of the stress hormone, corticosterone). It was hypothesized that if atrazine were to have estrogenic activity or to enhance endogenous estrogen production, there would be marked increases in the weights of estrogen sensitive tissues including the oviduct, the liver and the ovary together with changes in gonadotropin secretion. However, atrazine had no effect on either liver or ovary weights. Atrazine in the diet increased oviduct weights at 0.1 and 1 ppm in some studies. These effects were not consistently observed and were not significant when data from studies were combined. Systemic administration of atrazine ...Continue Reading

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Citations

Jun 19, 2013·General and Comparative Endocrinology·Mary Ann OttingerMahmoud Abdelnabi
Apr 15, 2009·General and Comparative Endocrinology·Florencia ReyMónica Muñoz-de-Toro
Nov 8, 2012·Journal of Biochemical and Molecular Toxicology·Sunny O AbarikwuEbenezer O Farombi
Aug 9, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Irene de la Casa-ResinoMarcos Pérez-López
Jun 7, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Catherine E WillettKristie M Sullivan

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