Lack of effects of trans fatty acids on eicosanoid biosynthesis with adequate intakes of linoleic acid

Lipids
J L Zevenbergen, E Haddeman

Abstract

The minimum requirement of linoleic acid to prevent effects of dietary C18 trans fatty acids on eicosanoid biosynthesis in rats was assessed. In a first experiment, six groups of animals were fed diets with a high content of trans fatty acids [20% of energy (en%)], and increasing amounts of linoleic acid (0.4 to 7.1 en%). In a second experiment, four groups of rats were fed diets designed to compare trans fatty acids with saturated and cis-monounsaturated fatty acids of the same chain length at the 2 en% linoleic acid level. After 9-14 weeks the biosynthesis of prostacyclin by pieces of aorta and the biosynthesis of hydroxy-heptadecatrienoic acid and 12-hydroxy-eicosatetraenoic acid by platelets were measured. The fatty acid compositions of aorta phospholipid and platelet lipid were also determined. Both the prostacyclin-production by aorta pieces and the production of hydroxy-heptadecatrienoic acid and 12-hydroxy-eicosatetraenoic acid by platelets appeared to be a linear function of the arachidonic acid level in aorta phospholipid and platelet lipid, irrespective of the trans fatty acid content in the diet. This indicates that trans fatty acids do not directly influence enzymes involved in eicosanoid biosynthesis. In a direct ...Continue Reading

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Citations

Nov 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P M Verschuren, J L Zevenbergen
Mar 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·J M Uscian, D W Stanley-Samuelson
Mar 1, 1990·The Journal of Nutritional Biochemistry·J E KinsellaJ W Whelan
Sep 1, 1994·Insect Biochemistry and Molecular Biology·G G Gadelhak, D W Stanley-Samuelson
Mar 1, 1996·Insect Biochemistry and Molecular Biology·D W Stanley-Samuelson, V K Pedibhotla
Jan 24, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M N Patel, D J Wright
Jan 1, 1996·Nutrition Research Reviews·M I Gurr
Mar 15, 2014·International Journal of Food Sciences and Nutrition·Camila Simonetti PaseMarilise Escobar Bürger

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