PMID: 11910594Mar 26, 2002Paper

Lack of effects of transdermal estradiol on diastolic function: a randomized placebo-controlled double-blind short-term trial

Climacteric : the Journal of the International Menopause Society
E Z FismanA Pines

Abstract

Limited information is available on the effects of transdermal estradiol on diastole. The present study was a randomized double-blind placebo-controlled trial designed to investigate the short-term effects of transdermal estradiol on left ventricular diastolic function in postmenopausal women. The study included 45 women aged 50.8 +/- 3.6 years (25 randomized to the study group and 20 to placebo), who underwent Doppler echocardiography and determination of the plasma estradiol level after 4 and 8 weeks of transdermal estradiol administration in a dose of 50 micrograms per 24 h. There were no modifications in heart rate. Systolic blood pressure dropped in the study patients after 8 weeks (p < 0.03); diastolic blood pressure remained unchanged. Estradiol levels were 67 +/- 36 pg/ml at 4 weeks and 70 +/- 49 pg/ml at 8 weeks in the study group. Basal values of peak early and peak atrial velocities, acceleration time and rate, deceleration time and rate, early/atrial velocity ratio and pressure half-time were not significantly different between the estradiol and placebo groups. Doppler values remained unchanged after both 4 and 8 weeks in women receiving estradiol. Women with relatively high serum 17 beta-estradiol levels (> 100 pg/...Continue Reading

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Citations

Nov 7, 2002·Current Hypertension Reports·Enrique Z FismanAmos Pines
Sep 23, 2008·Journal of Hypertension·Edoardo CasigliaAchille C Pessina
Jul 12, 2008·American Journal of Hypertension·Charles AgyemangKarien Stronks
Apr 22, 2011·American Journal of Hypertension·Licy L Yanes, Jane F Reckelhoff
Sep 2, 1999·Human Reproduction·E Z FismanA Pines
Mar 17, 2004·Hypertension·Jane F Reckelhoff, Lourdes A Fortepiani
Sep 23, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jian-Shu ChenJing Yu
Jun 16, 2021·Menopause : the Journal of the North American Menopause Society·Wendy YingDhananjay Vaidya

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