Lack of efficacy of clopidogrel pre-treatment in the prevention of myocardial damage after elective stent implantation

Journal of the American College of Cardiology
Dirk J van der HeijdenGert-Jan Laarman

Abstract

The object of this study was to determine the effect of pre-treatment with clopidogrel in patients undergoing elective stent implantation. The treatment of patients with adenosine diphosphate receptor blockers after percutaneous coronary intervention (PCI) with stent implantation has been shown to decrease the incidence of subacute stent thrombosis. Furthermore, non-randomized studies on pre-treatment with clopidogrel among patients undergoing stent implantation have suggested a reduction in myocardial damage and clinical events. The effect of pre-treatment with clopidogrel has been studied in only a few randomized trials. In a randomized trial, three days of pre-treatment with clopidogrel was compared with standard post-procedural treatment in 203 patients undergoing elective stent implantation. The primary end point was a rise in troponin I or creatine kinase-MB fraction (CK-MB) serum levels at 6 to 8 and 16 to 24 h after PCI. Secondary end points were death, stroke, myocardial infarction, coronary bypass grafting, repeated PCI, and subacute stent thrombosis at one and six months after PCI. No difference was found between non-pre-treated and pre-treated patients in the post-procedural elevation of troponin I (42 [43.3%] vs. 4...Continue Reading

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Citations

May 1, 2006·Future Cardiology·Udaya S TantryPaul A Gurbel
Nov 9, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Glenn N LevineUNKNOWN Society for Cardiovascular Angiography and Interventions
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Mar 14, 2007·Drugs·Greg L Plosker, Katherine A Lyseng-Williamson

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