Lack of efficacy of monepantel against Trichostrongylus colubriformis in sheep in Brazil

Veterinary Parasitology
M C R CintraC S Sotomaior

Abstract

Multiple drug resistance of nematodes against anthelmintics has become one of the most important economic problems in sheep production worldwide. The aim of this experiment was to evaluate the efficacy of monepantel (2.5mg/kg) against gastrointestinal nematodes in fecal egg count reduction test (FECRT) and controlled efficacy test (CT) in naturally infected sheep. We used 30 sheep for the FECRT and 20 sheep for the CT, equally divided into control and treated groups. In the FECRT, the reduction was 98%. Larval identification of pre-treatment coprocultures revealed 100% Haemonchus spp. for both control and treated groups. Post-treatment culture of treated sheep was 100% Oesophagostomum spp., but only few larvae were recovered. In the control group, they were 99% Haemonchus spp and 1% Oesophagostomum spp. larvae. Based on the FECRT, Haemonchus spp. was considered susceptible to monepantel. The efficacy of monepantel in the CT against Haemonchus contortus and Trichostrongylus axei was 100% and against Cooperia curticei was 99.7%. For Trichostrongylus colubriformis, the efficacy was -21.5%. In both treated and untreated animals, Oesophagostomum columbianum was recovered from the large intestines. Based on FECRT and CT and in accord...Continue Reading

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Citations

Nov 12, 2016·Preventive Veterinary Medicine·Stephanie EastonJacqueline B Matthews
Mar 17, 2016·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Jordana Andrioli Salgado, Clóvis de Paula Santos
Nov 15, 2018·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Francisca Flávia da SilvaVinícius Longo Ribeiro Vilela
Aug 3, 2018·Molecular Biology Reports·João Henrique Barbosa ToscanoAna Carolina de Souza Chagas
Jul 6, 2018·Parasites & Vectors·Mohammed H RashidAbdul Jabbar
Dec 10, 2019·Journal of Immunology Research·João Henrique Barbosa ToscanoAna Carolina de Souza Chagas
Dec 5, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Jordana Andrioli SalgadoClóvis de Paula Santos
Nov 30, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Jordana Andrioli SalgadoClóvis de Paula Santos
Sep 8, 2020·Parasite Immunology·João Henrique Barbosa ToscanoAna Carolina de Souza Chagas
Apr 3, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Candela CantonMariana Ballent
Jun 17, 2021·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·José Vilemar de Araújo-FilhoClaudia Maria Leal Bevilaqua
Sep 10, 2020·Veterinary Parasitology: X·João Henrique Barbosa ToscanoAna Carolina de Souza Chagas
Feb 16, 2019·Veterinary Parasitology: X·David J BartleyAlison A Morrison

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