Lack of efficacy of recombinant human thyrotropin versus thyroid hormone withdrawal for radioiodine therapy imaging in a patient with differentiated thyroid carcinoma lung metastases

Thyroid : Official Journal of the American Thyroid Association
D TaïebO Mundler

Abstract

The treatment of lung metastases of thyroid cancer is nearly exclusively limited to the administration of iodine-131. For patients presented with micronodular lesions, the therapeutic response is often excellent, increasing life expectancy. Because of the necessity of multiple iodine-131 treatments in the course of this therapy, and subsequently, the lack of tolerance of hormonal withdrawal, the use of recombinant human thyrotropin (rhTSH) as a method of stimulation could represent an interesting alternative. However, as in the present case, the stimulation by rhTSH can be less effective than hormonal withdrawal, as shown in the posttherapy scan to detect metastatic lesions and thus could be detrimental to the treatment efficiency.

References

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Citations

May 13, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraElif Hindié
Jan 21, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraDomenico Rubello
Sep 8, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-Fregonara, Elif Hindié
Sep 3, 2013·Indian Journal of Surgical Oncology·E Robenshtok, R Michael Tuttle
Nov 25, 2006·Thyroid : Official Journal of the American Thyroid Association·Richard J RobbinsUNKNOWN U.S. and Canadian Thyrogen Compassionate Use Program Investigator Group
Feb 9, 2012·Thyroid : Official Journal of the American Thyroid Association·Joanna Klubo-GwiezdzinskaLeonard Wartofsky
May 1, 2009·Expert Opinion on Medical Diagnostics·Muammer UrhanAbass Alavi
Dec 2, 2004·Expert Opinion on Pharmacotherapy·Loukas Gourgiotis, Monica C Skarulis
Dec 2, 2004·Expert Opinion on Pharmacotherapy·Mariusz W Szkudlinski
Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Joanna Klubo-GwiezdzinskaLeonard Wartofsky
Sep 17, 2013·The Journal of Clinical Endocrinology and Metabolism·Miguel MeloPaula Soares
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Debora ArpaiaBernadette Biondi
Jan 21, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Donika PlykuDouglas Van Nostrand

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