PMID: 16639063Apr 28, 2006Paper

Lack of enteral nutrition delays nuclear factor kappa B activation in peritoneal exudative cells in a murine glycogen-induced peritonitis model

JPEN. Journal of Parenteral and Enteral Nutrition
Chikara UenoHidetaka Mochizuki

Abstract

Early enteral nutrition is associated with a lower incidence of intraabdominal abscess in severely injured patients than parenteral nutrition (PN). We explored the underlying mechanisms by examining the influence of nutrition route on nuclear factor kappaB (NFkappaB) activation in peritoneal exudative cells (PECs) and peritoneal cytokine levels. Thirty male Institute Cancer Research mice were randomized to chow (n = 10), IV PN (n = 10), or intragastric (IG) PN (n = 10) and fed for 5 days. PECs were harvested at 2 or 4 hours after intraperitoneal injection of 2 mL of 1% glycogen. Intranuclear NFkappaB activity in PECs was examined by laser scanning cytometry. Cytokine (tumor necrosis factor-alpha [TNF-alpha], macrophage inflammatory protein-2 [MIP-2], interleukin-10 [IL-10]) levels in peritoneal lavaged fluid were determined by enzyme-linked immunosorbent assay. Intranuclear NFkappaB at 2 hours was significantly higher in the chow and IG-PN groups than in the IV-PN group. TNF-alpha and IL-10 levels of the chow group were significantly higher than those of IV-PN mice at 2 hours, whereas those of IG-PN mice were midway between those of the chow and IV-PN groups. MIP-2 was significantly higher in the chow group than in the IG-PN an...Continue Reading

References

Sep 1, 1991·The Journal of Surgical Research·J ShouJ M Daly
Apr 1, 1988·The Surgical Clinics of North America·M A MaddausR L Simmons
Jun 1, 1996·Annals of Surgery·K A KudskK B Renegar
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
Nov 2, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·W KangK Maekawa
Jan 18, 2003·American Journal of Surgery·Kenneth A Kudsk
May 22, 2003·JPEN. Journal of Parenteral and Enteral Nutrition·Woodae KangShigeo Ikeda

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Citations

Jul 27, 2011·The Surgical Clinics of North America·Kazuhiko Fukatsu, Kenneth A Kudsk
Jan 26, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Kazuhiko Fukatsu

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