Lack of evidence for the efficacy of enhanced surveillance compared to other specific interventions to control neonatal healthcare-associated infection outbreaks

Transactions of the Royal Society of Tropical Medicine and Hygiene
J BirtM Sharland

Abstract

Despite current prevention efforts, outbreaks of healthcare-associated infections in neonatal units remain high globally, with a considerable burden of mortality and morbidity. We searched Medline, Cochrane Library and Outbreak database to identify studies of neonatal healthcare-associated outbreaks between 2005 and 2015 that described interventions to control outbreaks. All studies were evaluated using the ORION guidance. Thirty studies were identified including 17 102 infants of whom 664 (3.9%) became infected. No single intervention was identified that reduced duration or mortality. Studies that introduced multiple interventions had significantly reduced case fatality ratio and outbreak duration compared to those that used basic surveillance only. Low and low-middle income countries reported the fewest interventions to control outbreaks and these studies were also associated with higher mortality than that found in middle and high income countries. Systematic reporting and formal evaluation of interventions used to reduce healthcare-associated neonatal infection outbreaks is key to identifying containment strategies worldwide.

References

Oct 16, 2007·The Journal of Hospital Infection·J A OtterG L French
Aug 30, 2008·The Journal of Hospital Infection·A M Kh Al JaroushaA S Al Afifi
Sep 11, 2008·Acta Paediatrica·V RabierP Bétrémieux
Feb 3, 2009·American Journal of Infection Control·Didier LepelletierChristèle Gras-Leguen
May 7, 2009·Indian Journal of Pediatrics·Murat AnilNeval Agus
Oct 30, 2010·Emerging Infectious Diseases·Sarah Tschudin-SutterAndreas F Widmer
Jan 24, 2012·American Journal of Infection Control·Helena C MaltezouAlkiviadis Vatopoulos
Aug 3, 2012·American Journal of Infection Control·Jennifer GrayKim Lindblade
Aug 21, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A N PintoM V N O'Sullivan
Feb 28, 2013·International Journal of Environmental Research and Public Health·Giuliana FabbriPatrizia Farruggia
May 15, 2013·American Journal of Infection Control·Elias IosifidisEmmanuel Roilides
Oct 17, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Sua SumerInci Tuncer

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Citations

Feb 6, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A DramowskiS Mehtar
Sep 1, 2017·Clinical Microbiology Reviews·Scott QuainooHeiman F L Wertheim

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