PMID: 8945087Nov 1, 1996Paper

Lack of evidence of areas of slow conduction early after radiofrequency current application at porcine atrial myocardium

Pacing and Clinical Electrophysiology : PACE
Thomas PaulR Brückner

Abstract

Electrophysiological sequelae after creation of atrial myocardial lesions by radiofrequency current (RFC) application have not been studied in vitro. During general anesthesia, a steerable 6 French electrode catheter, equipped with a thermistor at the 4-mm tip electrode, was positioned at the lateral atrial aspect of the tricuspid valve annulus in 5 piglets (German Landrace, mean body weight 12.5 kg). Temperature-guided (75 degrees C) RFC (500 kHz) was delivered over 30 seconds. Forty-eight hours later, the hearts were removed and placed in ice-cold Turner's solution. The right atria were dissected, and the RFC lesions with surrounding tissue were cut out and transferred to an organ bath according to Steiert. Preparations were superfused with Turner's solution at 37 degrees C. Pacing of the viable tissue at the border of the preparations was accomplished at a cycle length of 500 ms. Whole atrial preparations were impaled (76 to 150 impalements per specimen) with KCl capillary microelectrodes containing 3 MKCl. In the surrounding viable tissue of the five preparations, mean maximum diastolic transmembrane potential ranged from -61.3 to -63.7 mV, mean action potential duration at 90% repolarization ranged from 135.2 to 156.1 ms, ...Continue Reading

References

Jun 1, 1991·Journal of the American College of Cardiology·G F Van HareJ J Langberg
Feb 1, 1993·American Heart Journal·C E ChiangM S Chang

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Citations

Nov 24, 1998·Pacing and Clinical Electrophysiology : PACE·T LavergneM Haïssaguerre

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