Lack of Evidence That Male Fetal Microchimerism is Present in Endometriosis

Reproductive Sciences
Amelie FassbenderDan I Lebovic

Abstract

Fetal microchimerism has been implicated in the etiology of autoimmune diseases. This study was done to test the hypothesis that male fetal microchimerism is present in eutopic and ectopic endometrium (EM) obtained from women with endometriosis but not in eutopic EM from women without endometriosis. A total of 31 patients were selected, including women with endometriosis (paired eutopic and ectopic EM; n = 19) and women without endometriosis (eutopic EM; n = 12). Tricolor interphase fluorescence in situ hybridization analysis was performed by cohybridization of CEP Y SpectrumAqua and CEP X SpectrumGreen (SG)/CEP Y SpectrumOrange probes. Ectopic EM from women with endometriosis had 75% XX chromosomes (double SG signals) and 25% X chromosomes (single SG signal). Y chromosomes were not observed in any of the eutopic/ectopic endometrial tissues from cases or controls. We were unable to confirm our hypothesis that male fetal microchimerism is present in eutopic and/or ectopic EM obtained from women with endometriosis.

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Citations

Sep 1, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Amy M BoddyAthena Aktipis
Aug 16, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·W Niepiekło-MiniewskaP Kuśnierczyk
Feb 15, 2019·Reproductive Biology and Endocrinology : RB&E·Muzaffer A BhatDebabrata Ghosh

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Methods Mentioned

BETA
biopsy
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PCR

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Metasystems Isis

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