Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast

Human Pathology
Krisztina HanleyPing Tang

Abstract

Androgen receptor has been implicated in the pathogenesis of breast carcinoma. In this study, we explored the potential role of androgen receptor in breast cancer by analyzing its expression using immunohistochemistry and its relationship with tumor progress (ductal carcinoma in situ [DCIS] versus invasive ductal carcinoma [IDC]); nuclear grades (high grade [HG] versus non-high grade); expression of estrogen receptor (ER), progesterone receptor (PR), HER-2; and 3 molecular classifications: cytokeratin classification, triple (ER/PR/HER-2) negative classification, and ER/HER-2 classification in 184 breast carcinomas. We found that (1) lack of androgen receptor expression was associated with HG-IDC and with basal subtypes of HG-IDC, suggesting androgen receptor may play an important role in preventing the invasive transformation in this subgroup of breast carcinoma. (2) HG-IDC and HG-DCIS more frequently expressed androgen receptor than ER (55%-93% for androgen receptor and 18%-30% for ER) and were frequently androgen receptor+/ER- (63% for HG-DCIS and 39% for HG-IDC), which made androgen receptor a possible therapeutic target. (3) One third of HG-IDC was negative for androgen receptor, ER, PR, and HER-2, suggesting that further s...Continue Reading

References

May 6, 1995·Lancet·M J SilversteinD J Slamon
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Kuenen-BoumeesterS C Henzen-Logmans
Jun 5, 2003·Breast Cancer Research and Treatment·Els M J J BernsTheo H van der Kwast
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Nov 9, 2004·Maturitas·Woraluk Somboonporn, Susan R Davis
Mar 11, 2005·Expert Review of Anticancer Therapy·Scott M Dehm, Donald J Tindall
Jul 14, 2005·Virchows Archiv : an International Journal of Pathology·Irina MatosFernando Schmitt
Aug 3, 2005·Virchows Archiv : an International Journal of Pathology·Cristina RivaVincenzo Eusebi
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chad A LivasyCharles M Perou
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenneth J Pienta, Deborah Bradley
Mar 30, 2006·Virchows Archiv : an International Journal of Pathology·P ZagorianakouN J Agnantis
Apr 22, 2006·Virchows Archiv : an International Journal of Pathology·Walter SchippingerFarid Moinfar
Jul 26, 2006·Archives of Internal Medicine·Rulla M TamimiGraham A Colditz
Dec 6, 2006·Cancer·Emad A RakhaIan O Ellis

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Citations

Mar 1, 2012·Hormones & Cancer·Ulla SimanainenDavid J Handelsman
May 10, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laura C CollinsRulla M Tamimi
Nov 6, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S ParkK S Lee
May 10, 2011·Journal of Cancer·Sara A Lari, Henry M Kuerer
Jun 22, 2014·Endocrine-related Cancer·Keely M McNamaraWayne D Tilley
May 30, 2014·Endocrine-related Cancer·Cera M NietoScott D Cramer
Jan 5, 2013·Gynécologie, obstétrique & fertilité·R A Sakr
Feb 10, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mohammad Kazzem GheybiShokrollah Farrokhi
Sep 18, 2012·The Journal of Steroid Biochemistry and Molecular Biology·K M McNamaraH Sasano
Jul 10, 2016·Breast Cancer Research and Treatment·Giorgio SecretoVittorio Krogh
Aug 16, 2016·Breast Cancer Research and Treatment·Mohammad A AleskandaranyEmad A Rakha
Jul 22, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Enrique LermaJaime Prat
Dec 18, 2010·Magyar onkologia·Gábor RubovszkyMiklós Kásler
Oct 29, 2011·British Journal of Cancer·K B LundinH Jernström
Sep 27, 2014·Bulletin of Experimental Biology and Medicine·S S TodorovL M Nepomnyashchikh
Feb 15, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wedad M HannaSharon Nofech-Mozes
May 22, 2020·Breast Cancer Research and Treatment·Cristian ScatenaAntonio Giuseppe Naccarato
Mar 5, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rhonda S ArthurThomas E Rohan
Jul 10, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vittorio E BianchiAntonio Torsello
Jun 15, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Elisabeth S BergenRupert Bartsch

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