PMID: 6159540Oct 16, 1980Paper

Lack of heterogeneity in antihapten antibodies of a phylogenetically primitive shark

Nature
O Mäkelä, Gary W Litman

Abstract

Individual mammals have the capacity to express at least one million distinct antigen binding specificities, implying a high degree of structural heterogeneity in the variable heavy and light chain (VH and VL) portions of the antibody molecules. Studies of higher vertebrate species suggest that this heterogeneity is created both through a sizeable repertoire of germ-line VH and VL genes and through random rearrangements of V and joining genes. Additional somatic mechanisms probably also contribute to the ultimate heterogeneity; one-third of murine plasmacytomas producing lambda 1 immunoglobulin carry a somatically mutated Ig1-V gene. The relative contributions of these various mechanisms to the overall imunoglobulin variability are difficult to evaluate. The production of different antibodies to a defined determinant in different individuals of an inbred mouse strain [for example, (3-iodo-4-hydroxy-5-nitrophenyl) acetyl (NIP) in CBA mice] suggests the involvement of somatic mutations or rearrangement but does not rule out the possibility that each individual CBA mouse expresses only a small random fraction from a large germ-line repertoire of V genes determining different anti-NIP binding sites. The opposite finding, that diffe...Continue Reading

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Citations

May 28, 1982·Molecular and Cellular Biochemistry·G W LitmanO Mäkelä
Jan 1, 1985·Developmental and Comparative Immunology·T Matsunaga
Jan 1, 1985·Developmental and Comparative Immunology·G W LitmanR Litman
Jan 1, 1993·Developmental and Comparative Immunology·J J MarchalonisS F Schluter
Nov 7, 2001·Developmental and Comparative Immunology·Lars Pilström
Nov 1, 1996·Veterinary Immunology and Immunopathology·M F Flajnik
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G W LitmanB W Erickson
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M R WilsonG W Warr
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E HsuF W Alt
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A S GreenbergM F Flajnik
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J P Rast, G W Litman
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·R M BersteinJ J Marchalonis
Jan 23, 1999·Immunological Reviews·J J MarchalonisV S Hohman
Apr 15, 1994·Annals of the New York Academy of Sciences·J J Marchalonis, S F Schluter
Jan 1, 1996·Annual Review of Immunology·S D Wagner, M S Neuberger
Jun 8, 1999·Annual Review of Immunology·G W LitmanJ P Rast
Oct 12, 2013·BMC Genomics·Vincent P RichardsMahmood S Shivji
May 1, 1996·European Journal of Immunology·A S GreenbergM F Flajnik
Dec 1, 1982·Journal of Immunogenetics·G W LitmanO Mäkelä
Apr 1, 1987·British Journal of Addiction·B Saunders, S Allsop
Dec 1, 1983·British Journal of Addiction·G K LitmanP Jackson
Jan 1, 1983·Immunological Reviews·D R Bainbridge
Aug 9, 2005·Developmental and Comparative Immunology·John J MarchalonisPaul A Ramsland
Jul 1, 1995·Current Biology : CB·P Parham
Sep 9, 2005·Developmental and Comparative Immunology·H Dooley, M F Flajnik
Mar 21, 2018·Nature Reviews. Immunology·Martin F Flajnik

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