Lack of hippocampal involvement in a rat model of petit mal epilepsy

Epilepsy Research
A KandelG. Buzsáki

Abstract

Although petit mal epilepsy is believed to arise from the thalamocortical system, it has been suggested recently that high-voltage spike-and-wave activity (HVS) in mutant mice can cause structural reorganization in the hippocampus, similar to that seen in temporal lobe epilepsy. We tested this assumption in rat strains with low and high incidence of HVS. No relationship was found between mossy fiber sprouting and HVS incidence. Hippocampal neurons were not driven by HVS. These findings suggest that petit mal seizures do not invade the hippocampus and are not causally related to sprouting of the mossy fibers.

References

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Citations

Jan 17, 2016·Epilepsy Research·Justin ArcaroL Stan Leung
Sep 20, 2012·Epilepsy Research·Filiz Yılmaz OnatO Carter Snead
Jul 17, 2007·Seizure : the Journal of the British Epilepsy Association·Varsha SharmaRameshwar Singh
Dec 11, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B L C FerreiraC Timo-Iaria
Feb 7, 2007·Neuroscience Letters·Elena A Tolmacheva, Gilles van Luijtelaar
Jul 11, 2014·Journal of Neurophysiology·Daniel C Haggerty, Daoyun Ji
Aug 10, 2004·Toxicological Reviews·C Guin Ting WongO Carter Snead

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