PMID: 9557955Apr 29, 1998Paper

Lack of IL-1 receptor antagonistic activity of the capsular F1 antigen of Yersinia pestis

Immunology Letters
T Krakauer, D G Heath

Abstract

Because capsular F1 antigen of Yersinia pestis is reported to share sequence homology with interleukin-1 receptor antagonist (IL-1ra), we investigated the potential IL-1 receptor antagonistic activity of F1 on human endothelial cells (EC). The biological activities of IL-1 receptor antagonist (IL-1ra) or IL-1ra-like molecule were measured by its ability to suppress the IL-1beta-mediated induction of adhesion molecules (ICAM and ELAM) on EC and of IL-6 secretion by these cells. Two different, purified, immunogenic and biologically active preparations of F1, at concentrations up to 10-fold higher than that of IL-1ra, did not exhibit any inhibitory activities of IL-1ra. These F1 preparations also did not activate peripheral blood mononuclear cells to produce IL-4 or IL-10, cytokines which might downregulate pro-inflammatory cytokine production in response to infection. Thus, even though there is a high degree of similarity between F1 antigen and IL-1ra in three-dimensional structure by computer modeling and sequence homology, our work indicates that F1 antigen of Y. pestis does not have IL-1ra-like activity.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P H HartJ A Hamilton
Sep 1, 1972·The Journal of Infectious Diseases·R C WilliamsP G Quie
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
Mar 1, 1996·Infection·H M HasselhornF W Tiller

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