Lack of IL-6 increases blood-brain barrier permeability in fungal meningitis

Journal of Biosciences
Xiang LiLei Gao

Abstract

The pathogenesis of increased blood-brain barrier permeability during Cryptococcus meningitis is still largely unknown. Interleukin (IL-6) is a multifunctional cytokine, and numerous studies have shown that IL-6 influences the integrity of the blood-brain barrier. In this study we investigated the role of IL-6 in Cryptococcus meningitis. First, wild-type or IL-6(-/-) mice were injected with Cryptococcus neoformans (C. neoformans) and the survival time in both groups was recorded. Second, the number of fungi was measured in the brains of IL-6(-/-) wild-type mice. Finally, the blood-brain barrier permeability index was detected in infected IL-6(-/-) mice treated with recombinant human IL-6. The blood-brain barrier permeability index was measured in infected wild-type mice treated with anti-IL-6 antibodies as well. The survival of IL-6(-/-) mice injected with C. neoformans was significantly lower than that of identically challenged wild-type mice. The infected IL-6(-/-) mice had significantly larger brain fungal burdens than wild-type mice. Furthermore, increased blood-brain barrier index was found in infected IL-6(-/-) mice when compared with that in infected control mice. Similar results were obtained when mice challenged with C...Continue Reading

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Citations

Aug 16, 2016·Case Reports in Neurological Medicine·Kedar R MahajanLori Sheehan
Feb 9, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Yasmin HadianRoslyn Rivkah Isseroff
Jul 28, 2020·Journal of Fungi·Man Shun Fu, Rebecca A Drummond
Jul 7, 2021·Medical Microbiology and Immunology·Aline Beatriz Mahler PereiraAlexandre Paula Rogerio

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