PMID: 2123239Dec 1, 1990Paper

Lack of impact of early antibiotic therapy for streptococcal pharyngitis on recurrence rates

The Journal of Pediatrics
Michael A GerberE L Kaplan

Abstract

To determine whether recurrence rates for group A beta-hemolytic streptococcal (GABHS) pharyngitis are related to the time of initiation of antibiotic therapy, we randomly assigned 113 patients with GABHS pharyngitis either to a group that began a 10-day course of penicillin V at the time of diagnosis or to a group that began the same antibiotic regimen after a dealy of 48 hours. Follow-up throat culture specimens were obtained 4 days, 2 months, and 4 months after the completion of antibiotic therapy, as well as during any interim episodes of acute pharyngitis. Serotyping of all GABHS isolates was performed to distinguish between recurrences with homologous serotypes and new acquisitions with heterologous serotypes. There was no significant difference between the two treatment groups in age, gender, duration of illness before enrollment in the study, initial clinical presentation, or compliance. Of the 50 patients in the immediate-treatment group, 6 (12%) had homologous serotypes of GABHS isolated on one of the follow-up throat cultures. Of the 63 patients in the delayed-treatment group, 9 (14%) had homologous serotypes of GABHS isolated on one of the follow-up throat cultures. These data indicate that a 48-hour delay in the in...Continue Reading

References

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Citations

Jan 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P YagupskyR Dagan
Feb 26, 2004·Indian Journal of Pediatrics·Anita Shet, Edward Kaplan
Feb 25, 2005·Advances in Therapy·Alexander K C Leung, James D Kellner
Jul 1, 1996·Indian Journal of Pediatrics·K R Rajesh, R C Gordon
Jun 1, 2001·Current Infectious Disease Reports·Asher BarzilaiShlomo Sela
Nov 27, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael E Pichichero, Janet R Casey
Jan 21, 2014·The Lancet Infectious Diseases·Paul LittleUNKNOWN DESCARTE investigators
Jul 20, 2004·Clinical Microbiology Reviews·Michael A Gerber, Stanford T Shulman
Jul 9, 2004·The Journal of Pediatrics·Paul Little
May 1, 1993·Current Problems in Pediatrics·F W Denny
Jul 31, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·William NseirAdel Shalata
Sep 1, 1994·The Journal of Emergency Medicine·J A Kline, J W Runge
Mar 1, 1995·Annals of Emergency Medicine·M E Pichichero
Sep 8, 2017·The Cochrane Database of Systematic Reviews·Geoffrey Kp SpurlingRebecca Farley
Oct 3, 2006·Expert Review of Molecular Diagnostics·Alexander K C LeungH Dele Davies
Nov 17, 2019·International Journal of Environmental Research and Public Health·Michael G BakerDiana Lennon
Sep 4, 1998·The Pediatric Infectious Disease Journal·G Ruoff
Jun 22, 2002·The Pediatric Infectious Disease Journal·Urs B SchaadUNKNOWN Swiss Pharyngitis Study Group
Aug 9, 2001·Pediatric Emergency Care·H M Corneli
Jan 1, 1992·The Annals of Otology, Rhinology & Laryngology. Supplement·J L Paradise
Dec 26, 2009·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Hiroshi Sakata

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