Abstract
1. Angiotensin (Ang) II triggers the expression of a pro- oxidant phenotype in the vascular wall, suggesting that activation of the renin-angiotensin system (RAS) causes endothelial dysfunction in various pathological situations, such as hypertension. However, this hypothesis has been mostly tested in a setting of exogenous administration of AngII. 2. We tested the hypothesis of a role for endogenous activation of the RAS leading to oxidant stress and endothelial dysfunction in a high-renin model of hypertension (i.e. two-kidney, one-clip hypertension) in rats. One month after clipping or sham surgery, aorta were isolated from untreated rats or rats treated by the angiotensin AT1 receptor antagonist irbesartan (10 mg/kg per day). Mesenteric artery segments were also isolated from normotensive or hypertensive rats. 3. Hypertension reduced the relaxations to acetylcholine but did not affect the ratio of contractions to phenylephrine in the presence compared with the absence of a nitric oxide (NO) synthase inhibitor, used as an index of basal release of NO. 4. The free radical scavenger tempol reduced the contractions to phenylephrine in the absence, but not in the presence, of an inhibitor of NO synthesis. This index of free radi...Continue Reading
References
Apr 1, 1986·Hypertension·T F Lüscher, P M Vanhoutte
Feb 1, 1987·Hypertension·T F LüscherP M Vanhoutte
Nov 3, 1994·European Journal of Pharmacology·C LacourD Nisato
Jan 1, 1995·The Journal of Clinical Investigation·T MünzelD G Harrison
Jun 1, 1994·Circulation Research·K K GriendlingR W Alexander
Oct 1, 1993·Hypertension·G A GrayH R Baumgartner
Apr 15, 1996·The Journal of Clinical Investigation·S RajagopalanD G Harrison
Jan 1, 1997·Circulation Research·T FukuiK K Griendling
Dec 1, 1996·Journal of Hypertension·V RichardC Thuillez
Oct 23, 1997·Hypertension·K MatrouguiD Henrion
Apr 30, 1998·Circulation Research·H D WangR A Cohen
Sep 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·G LuvaràJ B Michel
Jan 20, 1999·Kidney International·T HeitzerT Münzel
Mar 9, 1999·Journal of Cardiovascular Pharmacology·J W CarrawayM J Radin
Dec 1, 1999·Circulation·H D IntenganE L Schiffrin
Mar 10, 2000·Journal of Cardiovascular Pharmacology·C ArtiguesC Thuillez
May 20, 2000·Hypertension·G ZalbaJ Díez
Feb 24, 2001·Hypertension·Akira NishiyamaYouichi Abe
Mar 7, 2001·Hypertension·L O LermanJ C Romero
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Feb 15, 1997·Environmental Toxicology and Pharmacology·D W LaightE E Anggård