Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals.

AIDS
David W OuyangRuth E Tuomala

Abstract

To estimate whether HIV-infected pregnant women were at an increased risk of hepatotoxicity when taking nevirapine (NVP)-containing regimens compared with HIV-infected pregnant women taking antiretroviral therapy (ART) not containing NVP. This analysis included HIV-infected pregnant women on ART from two multicenter, prospective cohorts: the Women and Infants Transmission Study and the International Maternal Pediatric Adolescent AIDS Clinical Trials protocol P1025. Multivariate Cox proportional hazards regression models were used to investigate the association between NVP use and hepatotoxicity. NVP use was dichotomized as use or no use and further categorized according to ART exposure history. We investigated two outcomes: any liver enzyme elevation (LEE) (grade 1-4) and severe LEE (grade 3-4). A total of 1229 women with ART use during pregnancy were studied, 218 (17.7%) of whom received NVP. Among the women receiving NVP, 137 (62.8%) were NVP naive. Twenty-nine women (13.3%) who received NVP developed any LEE and one (0.5%) developed severe LEE. Of the 1011 women on non-NVP regimens, 145 (14.3%) developed any LEE and 14 (1.4%) developed severe LEE. There were no maternal deaths. In univariate models, LEE was not significantly...Continue Reading

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Citations

Apr 25, 2012·Current HIV/AIDS Reports·Mariam Aziz, Kimberly Y Smith
Jul 29, 2010·Obstetrics and Gynecology·Elizabeth G LivingstonUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) Protocol 1025 Study Team
Feb 4, 2012·AIDS·Betty J DongUNKNOWN AIDS Clinical Trials Group Study 5208 Team
Sep 7, 2013·Journal of the International AIDS Society·Iris UsachJosé-Esteban Peris
May 24, 2011·Infectious Diseases in Obstetrics and Gynecology·Adriana WeinbergMyron J Levin
Nov 17, 2010·Clinics in Perinatology·Mark MirochnickDiana F Clarke
Jun 7, 2016·American Journal of Obstetrics and Gynecology·Alexander C EwingAthena P Kourtis
Oct 7, 2010·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Edgardo Gabriel BottaroLidia Isabel Cassetti
Feb 1, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeanne SibiudeUNKNOWN ANRS-French Perinatal Cohort Study Group
Sep 19, 2019·Journal of the International AIDS Society·Lee FairlieMatthew Chersich
Jan 22, 2015·HIV Medicine·Annemiek de RuiterUNKNOWN British HIV Association
Aug 10, 2021·World Journal of Hepatology·Priyanka KamathSheetal D Ullal

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