Lack of inhibition of glyceryl trinitrate by diphenyleneiodonium in bovine coronary artery

European Journal of Pharmacology
Ivan S de la LandeJohn D Horowitz

Abstract

Recent studies indicate that diphenyleneiodonium is a potent inhibitor of glyceryl trinitrate-induced relaxation in rat aorta precontracted with phenylephrine. We have explored the generality of this action in bovine coronary artery precontracted with the thromboxane A2 mimetic, 9,11-dideoxy-11 alpha, 9 alpha-epoxy-methano-prostaglandin F2 alpha (U46619). Diphenyleneiodonium 0.3 microM was without effect (endothelium absent) or caused mild potentiation (0.3 microM or 10 microM; endothelium present) of the relaxant response to gylceryl trinitrate. Lack of inhibition was not due to U46619, since inhibition was still prominent in rat aorta precontracted with this agent. It is concluded that diphenyleneiodonium distinguishes between cellular mechanisms mediating vasodilator responses to glyceryl trinitrate in rat aorta and bovine coronary artery.

References

Sep 24, 1992·The American Journal of Cardiology·H L FungE A Kowaluk
Jan 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D J StuehrC F Nathan
Jul 1, 1994·Trends in Pharmacological Sciences·B M BennettW C Simon
Mar 1, 1993·Clinical and Experimental Pharmacology & Physiology·M J Rand, C G Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.