Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test

British Journal of Clinical Pharmacology
A C ParkerI Choonara

Abstract

To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis. The caffeine breath test was carried out prior to the administration of cimetidine and after 2-3 weeks therapy. The children (n = 1) received 300-800 mg cimetidine daily (11-36 mg kg(-1) day(-1)). There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student's t-test P > 0.2). Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.

Citations

Nov 28, 2002·Alimentary Pharmacology & Therapeutics·A ArmuzziA Gasbarrini
Sep 8, 2000·Clinical Pharmacokinetics·J A Carrillo, J Benitez
Dec 1, 2007·Biomarkers in Medicine·Vlad C Vasile, Allan S Jaffe
May 4, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S FurutaH Sano
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gordon Jung-Hyuk ParkMeng Chong Ngu
Dec 7, 2005·Rapid Communications in Mass Spectrometry : RCM·Christine SlaterLawrence T Weaver
Oct 24, 2002·British Journal of Clinical Pharmacology·Joanne WatsonDavid Kerr
Mar 10, 1998·British Journal of Clinical Pharmacology·A C ParkerI Choonara

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