Lack of inotropic effects of neuropeptide Y in human myocardium.

Journal of Cardiovascular Pharmacology
M C MichelH J Motulsky

Abstract

The sympathetic co-transmitter neuropeptide Y (NPY) inhibits cardiac contractility in vivo in the rat heart. We tested whether NPY alters the force of contraction or the activity of adenylate cyclase in the isolated human right atrium. Neuropeptide Y did not affect basal-or isoproterenol-stimulated force of contraction and did not inhibit forskolin-stimulated adenylate cyclase activity. We conclude that NPY does not directly decrease cardiac contractility in humans. The inhibitory cardiac effects of NPY are likely to be secondary to coronary vasoconstriction, presynaptic inhibition of catecholamine release, and/or baroreflex activity.

Citations

Mar 1, 1991·Trends in Pharmacological Sciences·P WalkerB Waeber
Jul 21, 1994·Biochimica Et Biophysica Acta·N D WooP K Ganguly
Jan 1, 1992·Progress in Neurobiology·Y DumontR Quirion
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J WhartonK M Taylor
Apr 1, 1997·Expert Opinion on Investigational Drugs·M J Hudspith, R Munglani
Oct 11, 2008·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Victoria HildrethDeborah J Henderson
Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Danielle JacquesChantale Provost
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Danielle Jacques, Dima Abdel-Samad
Sep 1, 1995·Hypertension·N D Woo, P K Ganguly
Jan 1, 1990·Annals of the New York Academy of Sciences·J Wharton, J M Polak
Jul 25, 2017·Canadian Journal of Physiology and Pharmacology·Danielle JacquesGhassan Bkaily
May 1, 1997·Journal of Cardiovascular Pharmacology·L C RumpP Schollmeyer

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