PMID: 8938537Nov 1, 1996Paper

Lack of interaction between hepatitis C virus and alcohol in the pathogenesis of cirrhosis. A statistical study

Journal of Hepatology
M Alemy-CarreauA Gerolami

Abstract

In several studies markers of hepatitis C virus infection have been shown to be present in alcoholic patients with cirrhosis. Our work was designed to test the likely hypothesis that this association is due to an interaction between hepatitis C virus and alcohol in the pathogenesis of cirrhosis. We compared alcohol consumption and repartition of anti-HCV antibodies detected by an immunoblot recombinant assay in 101 male patients with cirrhosis and in 120 male controls. Interactions between anti-hepatitis C virus, alcohol and cirrhosis were calculated using log linear hierarchical models for frequency data. The basis of the method is that an interaction between hepatitis C virus and alcohol implies that a model built on the hypothesis of a role of hepatitis C virus and alcohol in the disease should be improved by a coefficient associated with multiplicative effects of hepatitis C virus and alcohol. In patients with cirrhosis the mean alcohol consumption (148 +/- 100 g per day) and the incidence of positivity for anti-HCV antibodies (45%) were significantly higher than in controls. The results were consistent with a theoretical model built with the hypothesis of an independent role of both alcohol and hepatitis C virus. The goodn...Continue Reading

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Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G OstapowiczP V Desmond
Jan 6, 2000·Journal of Hepatology·F Degos
Jan 25, 2003·Journal of Clinical Gastroenterology·Miguel A SerraJosé M Rodrigo
Feb 19, 2003·Journal of Clinical Gastroenterology·Renuka Bhattacharya, Margaret C Shuhart
Jun 26, 1998·Journal of Gastroenterology and Hepatology·M H KhanG C Farrell
Apr 7, 2007·Digestive Diseases and Sciences·Ahmad Kamal, Ramsey Cheung
May 29, 2004·The Journal of General Virology·Søren U NielsenGeoffrey L Toms

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