Abstract
Alzheimer disease (AD) has a heterogeneous aetiology, involving genetic and environmental factors. Low-density lipoprotein receptor-related protein 1 (LRP1), alpha-2-macroglobulin (A2M) and apolipoprotein E (APOE) are involved in molecular pathways leading to beta-amyloid deposition. Three polymorphic sites in these genes (APOE-epsilon 2/epsilon 3/epsilon 4, A2M-Ile/Val and LRP1-C/T) have been associated with AD, but the results were not univocal. We carried out a case-control study to investigate the association between these polymorphisms and the risk of developing AD and their possible interaction. We recruited 125 AD patients who fulfilled the diagnostic criteria proposed by NINCDS-ADRDA for probable or possible AD and 310 controls subjects. PCR was used to detect the polymorphisms. ORs and 95% CIs were estimated using logistic regression analysis. The OR for subjects carrying at least one allele Val (A2M-Val+) in their genotypes was 1.52 (95% CI 1.00-2.31; p=0.05); for subjects carrying at least one allele C (LRP1-C+), 1.58 (95% CI 1.00-2.50; p=0.05); for subjects carrying at least one allele epsilon 4 (APOE-epsilon 4+), 3.1 (95%CI 1.87-5.00; p<0.001). The coexistence of at least one allele Val (A2M-Val+) and one allele C ...Continue Reading
References
Jul 1, 1979·Acta Psychiatrica Scandinavica·C CaltagironeG Miceli
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Aug 13, 1993·Science·E H CorderM A Pericak-Vance
Jan 1, 1996·European Neurology·G A CarlesimoG Gainotti
Jul 1, 1997·Neurology·D E KangR Katzman
Oct 23, 1997·JAMA : the Journal of the American Medical Association·M A Pericak-VanceJ L Haines
Jun 20, 1998·Neurology·E HollenbachG W Rebeck
Aug 26, 1998·JAMA : the Journal of the American Medical Association·W S WuA Goate
Feb 11, 2000·Neurology·R C DodelS M Paul
Mar 11, 2000·American Journal of Human Genetics·W K ScottM A Pericak-Vance
Dec 13, 2000·Neurology·B DuboisB Pillon
Apr 5, 2001·Brain : a Journal of Neurology·G GainottiG Villa
Sep 11, 2002·Neurology·M ZappiaA Quattrone
Mar 17, 2004·Archives of Neurology·Mario ZappiaAldo Quattrone
Jul 5, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I AppollonioP Nichelli
Jul 26, 2005·Biological Psychiatry·Li BianLin He
Sep 27, 2005·Mechanisms of Ageing and Development·Francesco PanzaVincenzo Solfrizzi
Citations
Sep 17, 2013·PloS One·Xuting XuShiwei Duan
Mar 22, 2014·PloS One·Fabíola C R ZucchiGerlinde A S Metz
Apr 24, 2014·Cell Biochemistry and Biophysics·Hui ChenGuangming Zhu
Jan 29, 2013·Annual Review of Biochemistry·Amy R WyattMark R Wilson
May 7, 2011·The International Journal of Neuroscience·M ObulesuR Venu
Dec 17, 2014·The International Journal of Neuroscience·Xingzhi GuoRui Li
Jan 18, 2012·Journal of Molecular Biology·Amy R WyattMark R Wilson
Nov 12, 2016·BMC Genomics·James DenvirJung Han Kim
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Maria LucaAntonina Luca
Jun 13, 2021·Neurochemistry International·Sibo YangBo Hu