Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease

Neuroscience Letters
Elisa BrunoMario Zappia

Abstract

Alzheimer disease (AD) has a heterogeneous aetiology, involving genetic and environmental factors. Low-density lipoprotein receptor-related protein 1 (LRP1), alpha-2-macroglobulin (A2M) and apolipoprotein E (APOE) are involved in molecular pathways leading to beta-amyloid deposition. Three polymorphic sites in these genes (APOE-epsilon 2/epsilon 3/epsilon 4, A2M-Ile/Val and LRP1-C/T) have been associated with AD, but the results were not univocal. We carried out a case-control study to investigate the association between these polymorphisms and the risk of developing AD and their possible interaction. We recruited 125 AD patients who fulfilled the diagnostic criteria proposed by NINCDS-ADRDA for probable or possible AD and 310 controls subjects. PCR was used to detect the polymorphisms. ORs and 95% CIs were estimated using logistic regression analysis. The OR for subjects carrying at least one allele Val (A2M-Val+) in their genotypes was 1.52 (95% CI 1.00-2.31; p=0.05); for subjects carrying at least one allele C (LRP1-C+), 1.58 (95% CI 1.00-2.50; p=0.05); for subjects carrying at least one allele epsilon 4 (APOE-epsilon 4+), 3.1 (95%CI 1.87-5.00; p<0.001). The coexistence of at least one allele Val (A2M-Val+) and one allele C ...Continue Reading

References

Jul 1, 1979·Acta Psychiatrica Scandinavica·C CaltagironeG Miceli
Oct 23, 1997·JAMA : the Journal of the American Medical Association·M A Pericak-VanceJ L Haines
Aug 26, 1998·JAMA : the Journal of the American Medical Association·W S WuA Goate
Feb 11, 2000·Neurology·R C DodelS M Paul
Dec 13, 2000·Neurology·B DuboisB Pillon
Mar 17, 2004·Archives of Neurology·Mario ZappiaAldo Quattrone
Jul 5, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I AppollonioP Nichelli
Sep 27, 2005·Mechanisms of Ageing and Development·Francesco PanzaVincenzo Solfrizzi

❮ Previous
Next ❯

Citations

Jan 29, 2013·Annual Review of Biochemistry·Amy R WyattMark R Wilson
Dec 17, 2014·The International Journal of Neuroscience·Xingzhi GuoRui Li
Jan 18, 2012·Journal of Molecular Biology·Amy R WyattMark R Wilson
Nov 12, 2016·BMC Genomics·James DenvirJung Han Kim
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Maria LucaAntonina Luca
Jun 13, 2021·Neurochemistry International·Sibo YangBo Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

© 2021 Meta ULC. All rights reserved