PMID: 2488686Jan 1, 1989Paper

Lack of interaction of HLA and IgG heavy chain allotypes in insulin-dependent diabetes mellitus

Experimental and Clinical Immunogenetics
M J SheehyJ P Pandey

Abstract

Because of conflicting previous reports showing the presence or absence of Gm-HLA interaction in insulin-dependent diabetes mellitus (IDDM), we report results for a group of Wisconsin families having 2 or more siblings with IDDM. Although this study is very similar to one by Field et al., who found HLA-Gm interaction in IDDM, we find no evidence for such an interactive effect p = 0.33). We discuss published data on HLA-Gm interaction in IDDM, and conclude that overall there is little reason to postulate such an interaction.

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