Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents

Epilepsia
Lukas CervenyZdenek Fendrich

Abstract

Recent studies have indicated constitutive expression of efflux transporter, breast cancer resistance protein (BCRP, ABCG2), in endothelial cells of the blood-brain barrier (BBB). In epileptogenic brain tumors such as ganglioma, astrocytoma, anaplastic astrocytomas, or glioma multiforme, strong expression of BCRP in the microvasculature of the BBB was observed. Therefore it was hypothesized that this phenomenon could critically influence the bioavailability of drugs in these tumors and potentially contribute to the failure of antiepileptic treatment. The aim of this study was to test whether some commonly used antiepileptic drugs (AEDs) are substrates transported by human BCRP. In particular, we focused on phenobarbital, phenytoin, ethosuximide, primidone, valproate, carbamazepine, clonazepam, and lamotrigine. Furthermore, the inhibitory potency of these AEDs to BCRP was examined. To study substrate affinity of tested AEDs to BCRP, transport experiments were performed in epithelial BCRP-expressing MDCKII-BCRP and MDCKII-parent cell lines cultured on microporous membrane. For detection of inhibitory potency of AEDs to BCRP, accumulation assays were carried out in MEF3.8-BCRP cells with known BCRP substrates, BODIPY FL prazosin a...Continue Reading

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Mar 17, 1998·Biochemical and Biophysical Research Communications·H Huai-YunD W Miller
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·V V RaoD Piwnica-Worms
Apr 21, 1999·Epilepsy Research·G Regesta, P Tanganelli
Jun 24, 1999·Journal of Clinical Pharmacy and Therapeutics·E Tanaka
Jan 24, 2002·Therapeutic Drug Monitoring·Houda HachadRene H Levy
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Wolfgang Löscher, Heidrun Potschka
Jan 22, 2003·Advanced Drug Delivery Reviews·Alfred H Schinkel, Johan W Jonker
Mar 29, 2003·The Journal of Pharmacology and Experimental Therapeutics·Heidrun PotschkaWolfgang Löscher
Apr 11, 2003·The New England Journal of Medicine·Asra SiddiquiSanjay M Sisodiya
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Johanna WeissWalter Emil Haefeli

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Citations

Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Margaret F Bennewitz, W Mark Saltzman
May 20, 2009·Pharmacogenomics·Dalia Kasperaviciūte, Sanjay M Sisodiya
Nov 22, 2014·Nanomedicine·Sukrut Somani, Christine Dufès
Jan 8, 2013·Expert Opinion on Drug Metabolism & Toxicology·Rebecca Schnepf, Oliver Zolk
Sep 22, 2015·Biopharmaceutics & Drug Disposition·Zuzana NeumanovaFrantisek Staud
Dec 17, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jakub HofmanFrantisek Staud
Dec 6, 2011·Advanced Drug Delivery Reviews·Eleonora AronicaJan A Gorter
Aug 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ander Estella-Hermoso de MendozaMaría J Blanco-Prieto
Dec 18, 2015·European Journal of Pharmacology·Maria D DonovanBrendan T Griffin
Jul 6, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wei TianWan-Liang Lu
Sep 29, 2009·International Journal of Pharmaceutics·Pallabi Mitra, Kenneth L Audus
Aug 18, 2012·Journal of Veterinary Pharmacology and Therapeutics·V ZancanellaM Dacasto
Jul 15, 2015·Reproductive Toxicology·Zuzana NeumanovaFrantisek Staud
Jul 14, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bhavani Prasad KotaBasil D Roufogalis
Apr 17, 2007·Lancet Neurology·Melanie S M van BreemenCharles J Vecht
Oct 18, 2006·The Journal of Pharmacology and Experimental Therapeutics·Steffen BaltesWolfgang Löscher
Mar 4, 2008·Molecular Pharmacology·Robert W RobeySusan E Bates
Mar 19, 2020·Pharmacogenetics and Genomics·Taraswi Mitra-GhoshRuss B Altman
Jun 17, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ali HusainSaad Makhseed
Mar 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gurpreet Kaur GrewalRitushree Kukreti
Jul 22, 2017·Frontiers in Neurology·Fei TangBjörn Bauer
Nov 23, 2017·Frontiers in Oncology·Fatma E El-KhoulySophie E M Veldhuijzen van Zanten
Dec 15, 2012·Pharmacological Reports : PR·Karolina M StępieńStanisław J Czuczwar
May 29, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Katherine E HamiltonStephanie J Phelps
Jun 27, 2019·International Journal of Molecular Sciences·Hyeong Sim ChoiPil-Young Yun
Feb 22, 2021·Journal of Pharmaceutical Sciences·Mauricio A GarcíaPeter Langguth
Aug 7, 2021·F1000Research·Samuel J TollNorman R Saunders

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