PMID: 7541299Mar 1, 1995Paper

Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats

Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration
G BagettaG Nisticò

Abstract

The gross behavioural, electrocortical and neuropathological effects of kainate (10 mg/kg i.p,) and ouabain (1 micrograms, given into one dorsal hippocampus) were studied in rats. The effects of these treatments on nitric oxide synthase (NOS) activity in homogenates of hippocampus and cortex were also studied. Administration of kainate or ouabain produced motor and electrocortical seizures similar for latency to onset (approximately 15 min) and intensity (in all instances 80-100% of the treated rats showed behavioural and electrographic seizures). These effects were accompanied at 24 h by severe damage to all subsectors of the hippocampal formation and this concerned a similar proportion of the treated rats (n = 4-8 per treatment). No significant changes in nitric oxide synthase (NOS) activity were noted in the cerebral cortex and hippocampus of rats receiving injections of kainate and ouabain. In addition, pretreatment with N omega-Nitro-L-arginine methyl ester (300 micrograms, given into one lateral cerebral ventricle 15 min previously) was ineffective in preventing the effects of kainate and ouabain. In conclusion, present data suggest that excessive production of NO is not involved in the mechanisms triggering seizures and ...Continue Reading

Citations

Mar 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T N FerraroW H Berrettini
Mar 8, 2011·Molecular Neurobiology·Richard KillickMassimiliano Agostini
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·Amanpreet SinghShrinivas K Kulkarni
Sep 11, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Lidija RadenovicMarina Jovanovic
Feb 16, 2002·Biochemical and Biophysical Research Communications·Giacinto BagettaM Tiziana Corasaniti
Mar 9, 2012·Neurochemical Research·Abdullah Hilmi MarangozCafer Marangoz
Dec 1, 1996·Japanese Journal of Pharmacology·Y MurataA Baba

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