Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice

Neuroscience Letters
Michiyoshi HatanakaAkemichi Baba

Abstract

PACAP is a neurotransmitter involved in the signal transduction of light stimulation in the suprachiasmatic nucleus (SCN). Light stimulation affects autonomic nerve activity via the SCN, and here we tested whether PACAP participates in light-induced regulation of sympatho-adrenal activity by using PACAP-deficient (Adcyap1(-/-)) mice. Light stimulation (100 lux, 30 min) significantly elevated both renal sympathetic nerve activity (RSNA), which was monitored on a digital oscilloscope, and plasma corticosterone levels in wild-type mice, but both responses were almost abolished in Adcyap1(-/-) mice. Although light-induced c-Fos expression in the SCN was observed in both genotypes, the numbers of c-Fos positive cells were significantly decreased in Adcyap1(-/-) mice. These data suggest that PACAP signaling pathway is involved in light-induced stimulation of RSNA and plasma corticosterone release through SCN of brain.

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Citations

Apr 25, 2012·Journal of Molecular Neuroscience : MN·D ReglodiA Tamas
May 21, 2010·Journal of Biological Rhythms·Christopher M JungKenneth P Wright
Oct 12, 2015·Journal of Molecular Neuroscience : MN·Andrea TamasZalan Szanto
Jan 9, 2014·Chronobiology International·Mark A Oldham, Domenic A Ciraulo
Mar 29, 2011·Stress : the International Journal on the Biology of Stress·Naohiro TsukiyamaAkemichi Baba
Oct 23, 2018·GeroScience·D ReglodiA Bardosi
Jul 10, 2019·Current Topics in Medicinal Chemistry·Chenyi LiaoJianing Li
Mar 13, 2020·Stress : the International Journal on the Biology of Stress·Katja PetrowskiBjarne Schmalbach
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing Han, Jiangping Wu
Jul 30, 2020·Stress : the International Journal on the Biology of Stress·Katja PetrowskiBjarne Schmalbach
Jan 19, 2021·Endocrinology·Nadejda Bozadjieva-KramerJonathan N Flak

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