Lack of linkage between HLA and multiple endocrine neoplasia type 2 in a French family

Tissue Antigens
P PerrierF Streiff

Abstract

In this study, linkage between HLA and a dominant gene determining multiple endocrine neoplasia type 2 (MEN 2) in a large pedigree was investigated. All lod scores for recombination fractions ranging from 0 to 0.45 were negative. If we pool data from our family and the families studied by Jackson et al. (1976) and Simpson & Falk (1982), a link between HLA and the locus for MEN 2 can be excluded. Linkage studies with various markers and pooled data should be pursued to permit detection of high risk individuals and to identify a genetic defect.

References

Feb 1, 1983·Clinical Genetics·K H GustavsonK Oberg
Jul 1, 1983·Cancer Genetics and Cytogenetics·K EmmertsenG B Petersen
Jul 1, 1984·Journal of the Royal Society of Medicine·B A Ponder
Dec 1, 1982·The Journal of Pediatrics·R F GagelA H Tashjian

Citations

Jan 1, 1988·Animal Genetics·J J McClure

Related Concepts

HLA Antigens
Genetic Linkage Analysis
Lod Score
Multiple Endocrine Neoplasia
Genealogical Tree

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