PMID: 9450887Feb 5, 1998

Lack of linkage disequilibrium between transforming growth factor alpha Taq I polymorphism and cleft lip with or without cleft palate in families from Northeastern Italy

American Journal of Medical Genetics
L ScapoliM Tognon


Cleft lip with or without cleft palate (CL +/- P) is the most frequent craniofacial malformation in different human populations and its cause is largely unknown. Several studies based on population associations have suggested that an allele mapping in the transforming growth factor alpha locus could be responsible, as a risk factor, for the development of the defect. Our investigation of the Taq I polymorphism at the transforming growth factor alpha locus, performed in 40 CL +/- P families, did not find evidence for linkage disequilibrium with particular alleles. Moreover, tight linkage was excluded with the traditional LOD score method.


Jul 4, 2007·International Journal of Pediatric Otorhinolaryngology·F CarinciF Pezzetti
Jul 14, 2006·International Journal of Pediatric Otorhinolaryngology·Rosario RulloF Carinci
Apr 5, 2005·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·F CarinciFernando Gombos

Related Concepts

Cleft Lip
Cleft Palate, Isolated
Genetic Polymorphism
Linkage Disequilibrium
Transforming Growth Factor alpha
Loss of Heterozygosity
Taq Polymerase

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