Lack of long-term effects of high-dose inhaled beclomethasone for respiratory syncytial virus bronchiolitis: a randomized placebo-controlled trial

The Pediatric Infectious Disease Journal
Kim Zomer-KooijkerRSV Corticosteroid Study Group

Abstract

Previously, we showed that high-dose early initiated inhaled corticosteroids during respiratory syncytial virus bronchiolitis partially and transiently prevents subsequent recurrent wheeze. Here, we study treatment effect on lung function at age 6. This is a 6-year follow-up report of a randomized placebo-controlled trial, in which 185 infants hospitalized for respiratory syncytial virus bronchiolitis were treated with early initiated, high-dose inhaled beclomethasone (n = 86) or placebo (n = 99) for 3 months. The primary outcome was forced expiratory volume in 1 second as percentage predicted. Secondary outcomes were bronchial hyperresponsiveness, physician-diagnosed asthma, hay fever and eczema. Possible toxicity was assessed by linear growth measurements. At age 6, no significant differences were found in mean forced expiratory volume in 1 second percentage predicted between beclomethasone-treated and placebo-treated patients (91.4 vs. 93.4, mean difference 2.05 (95% confidence interval: -1.98 to 6.08). The proportion of bronchial hyperresponsiveness, physician-diagnosed asthma, parent reported hay fever and eczema was comparable between groups. There were no differences in linear growth. Early initiated prolonged treatment ...Continue Reading

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Citations

Apr 16, 2014·The Pediatric Infectious Disease Journal·Matti Korppi
Feb 24, 2016·Expert Review of Respiratory Medicine·Silvia VandiniMarcello Lanari
Feb 26, 2015·The Journal of Infectious Diseases·Eric A F SimõesRichard J Whitley
Nov 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thi Hiep NguyenMing Yang
Apr 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thi Hiep NguyenMing Yang

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