PMID: 9178372Apr 1, 1997Paper

Lack of long-term facilitation of ventilation after exposure to hypoxia in goats

Respiration Physiology
M R DwinellG E Bisgard

Abstract

Episodic hypoxia has been shown to induce augmented normoxic ventilatory drive or long-term facilitation (LTF, continued hyperventilation after termination of hypoxic stimulation) in awake dogs and awake goats. The main objective of these experiments was to examine whether continuous isocapnic hypoxia in awake goats elicits LTF and additionally, to determine if goats exhibit hypoxic ventilatory decline (roll-off) during the hypoxic exposure. Goats were exposed to either 4 h of isocapnic hypoxia (n = 10) or 30 min of isocapnic hypoxia (n = 7). Ventilation (VE), tidal volume and frequency were measured before, during and following the end of the isocapnic hypoxia (PaO2 40 Torr) exposure. During the 4 h period of hypoxia, VE increased in a time-dependent manner in a typical pattern of acclimatization, reaching a mean of 40.8 +/- 3.6 L/min at the end of 4 h. Five minutes after return to normoxia, VE was 13.0 +/- 0.8 L/min, not different than control VE (13.1 +/- 0.9 L/min) measured prior to the hypoxic exposure and remained unchanged from this value for another 30 min. During the 30 min hypoxic exposure, VE increased upon exposure to hypoxia, remained significantly elevated throughout the hypoxic exposure, but promptly returned to ...Continue Reading

References

Jul 1, 1992·Respiration Physiology·K Y CaoC E Sullivan
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Feb 1, 1996·Respiration Physiology·W M GershanA K Garber
Jul 1, 1996·Respiration Physiology·K B Bach, G S Mitchell

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Citations

Aug 30, 2000·Respiration Physiology·K F MorrisB G Lindsey
Aug 30, 2000·Respiration Physiology·D D FullerG S Mitchell
Aug 26, 1998·Respiration Physiology·F L PowellG S Mitchell
Aug 23, 2011·Integrative and Comparative Biology·Henner KochJan-Marino Ramirez
Mar 3, 2007·Respiratory Physiology & Neurobiology·Michelle McGuireChi-Sang Poon
Mar 28, 2013·Annals of the New York Academy of Sciences·Michael J DevinneyGordon S Mitchell
Nov 10, 2006·Journal of Neurophysiology·Kathleen J S GriffioenDavid Mendelowitz
Aug 4, 1998·The American Journal of Physiology·S J Heitman, D B Jennings
May 18, 2001·Journal of Applied Physiology·G S MitchellE B Olson
Jun 24, 2003·Journal of Applied Physiology·Michelle McGuireLiming Ling
Oct 23, 2002·Journal of Applied Physiology·Ryan W Bavis, Gordon S Mitchell
Oct 23, 2002·Journal of Applied Physiology·Michelle McGuireLiming Ling
May 31, 2002·Journal of Neurophysiology·Dawn M Blitz, Jan-Marino Ramirez
Jul 18, 2001·Journal of Applied Physiology·E B OlsonG S Mitchel

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