Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats

Reproductive Toxicology
Hironori TakagiMasao Hirose

Abstract

We previously found that effects of perinatal dietary exposure to ethinylestradiol (EE) on the rat reproductive system differ depending on the diet used, with a more pronounced estrogenic impact with a regular diet that includes soy-derived proteins than with a soy-free (SF) diet. The present study was performed to examine whether genistein (GEN), a soy-derived major phytoestrogen, acts synergistically with EE. Maternal rats were fed SF diet without chemical (control) or containing 0.5-ppm EE, 0.5-ppm EE + 100-ppm GEN, 0.5-ppm EE + 1250-ppm GEN, or 1250-ppm GEN, from gestational day 15 to postnatal day (PND) 11. EE reduced serum testosterone in males at PND 3, and affected the onset of puberty of both sexes and estrous cyclicity and reproductive system in females, irrespective of co-administration of GEN. GEN alone also affected estrous cyclicity and the reproductive system in females. However, no combination effects of GEN with EE were evident, suggesting no synergism between the two.

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Citations

Sep 29, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gail McCarverKatie Turner
Mar 21, 2012·International Journal of Andrology·K R MandrupJ Boberg
Sep 17, 2013·Reproductive Toxicology·Karen Riiber MandrupJulie Boberg
Nov 2, 2013·Toxicology Letters·Gerhard J NohynekKarl K Rozman
Mar 5, 2017·Environmental Research·Kristin J MarksMichele Marcus
Sep 15, 2012·Korean journal of pediatrics·Shin Hye Kim, Mi Jung Park
Dec 23, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Karl K RozmanDavid Umbach
Apr 18, 2015·Annals of Pediatric Endocrinology & Metabolism·Byung Ho KangKye Shik Shim
Mar 28, 2006·Journal of Natural Products·Susan Reinwald, Connie M Weaver

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