Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure

The European Journal of Neuroscience
Miyuki SakumaC J Woolf

Abstract

Motor axons in peripheral nerves have the capacity to regenerate after injury. However, full functional motor recovery rarely occurs clinically, and this depends on the nature and location of the injury. Recent preclinical findings suggest that there may be a time after nerve injury where, while regrowth to the muscle successfully occurs, there is nevertheless a failure to re-establish motor function, suggesting a possible critical period for synapse reformation. We have now examined the temporal and anatomical determinants for the re-establishment of motor function after prolonged neuromuscular junction (NMJ) denervation in rats and mice. Using both sciatic transection-resuture and multiple nerve crush models in rats and mice to produce prolonged delays in reinnervation, we show that regenerating fibres reach motor endplates and anatomically fully reform the NMJ even after extended periods of denervation. However, in spite of this remarkably successful anatomical regeneration, after 1 month of denervation there is a consistent failure to re-establish functional recovery, as assessed by behavioural and electrophysiological assays. We conclude that this represents a failure in re-establishment of synaptic function, and the possi...Continue Reading

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Citations

Sep 9, 2016·Annals of Clinical and Translational Neurology·Philippe MagownVictor F Rafuse
Jul 28, 2016·Journal of Muscle Research and Cell Motility·Feng PanYong-Jun Rui
Apr 27, 2017·The European Journal of Neuroscience·Heng Li, Wutian Wu
Dec 7, 2019·Journal of Biomedical Materials Research. Part a·Hui GongHarry H Chen
Apr 24, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·David Romeo-GuitartCaty Casas
Apr 3, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Carolyn TallonMohamed H Farah
Oct 14, 2020·Journal of Tissue Engineering and Regenerative Medicine·Joseph C MaggioreD Kacy Cullen
Dec 19, 2020·Biological Reviews of the Cambridge Philosophical Society·Diego ZeladaJuan P Henríquez
Jan 13, 2021·Neural Regeneration Research·Shi-Qin Lv, Wutian Wu
Oct 4, 2020·Plastic and Reconstructive Surgery·Erin L WeberMitchel Seruya
Mar 2, 2021·Neural Regeneration Research·Katherine L Marshall, Mohamed H Farah

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