Lack of Mutagenicity of Polycyclic Musk Fragrances in Salmonella typhimurium

Toxicology in Vitro : an International Journal Published in Association with BIBRA
V Mersch-SundermannC Jenter

Abstract

Synthetic musks are widely used as fragrances and therefore found in various environmental samples. Residues were identified in river and waste water, animal and human tissues and breast milk. In the present study, six artificial polycyclic musk fragrances-Galaxolide, Tonalide, Celestolide, Phantolide, Cashmeran and Traseolide-were tested for mutagenicity using the Salmonella/mammalian-microsome assay with Salmonella typhimurium strains TA97, TA98, TA100 and TA102 in the presence (+S-9) and absence (-S-9) of an exogenous metabolizing system. All compounds tested exhibited no mutagenicity in the Salmonella assay. These results could be rated as one indicator of the biological inactivity of this group of chemicals with respect to genotoxicity.

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Citations

Feb 18, 1998·Mutation Research·S KevekordesH Dunkelberg
Sep 24, 2002·Toxicology Letters·Lilianne Abramsson-Zetterberg, Premysl Slanina
Aug 1, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiD K Wilcox
Mar 17, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiJ Wahler
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Jun 6, 2021·Environmental Science and Pollution Research International·Xixi LiBaiyu Zhang

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