Lack of new antiinfective agents: Passing into the pre-antibiotic age?

World Journal of Biological Chemistry
Klaus Brandenburg, Tobias Schürholz

Abstract

The lack of newly developed antibiotics, together with the increase in multi-resistance of relevant pathogenic bacteria in the last decades, represents an alarming signal for human health care worldwide. The number of severely infected persons increases not only in developing but also in highly industrialized countries. This relates in first line to the most severe form of a bacterial infection, sepsis and the septic shock syndrome, with high mortality on critical care units. No particular anti-sepsis drug is available, and the therapy with conventional antibiotics more and more fails to provide a survival benefit. Due to the fact that the pharmaceutical industry has withdrawn to a high degree from the development of anti-infectious agents, a huge challenge for health care is approaching in the 21(st) century. In this article, these problems are outlined and possible alternatives are presented which may be helpful to solve the problem.

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Citations

Dec 23, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin Davido, Aurélien Dinh
Jan 24, 2016·Biochimica Et Biophysica Acta·Klaus BrandenburgKarl Lohner
Sep 2, 2016·Veterinary Dermatology·Stefan SchwarzKristina Kadlec
Dec 26, 2016·Biochimica Et Biophysica Acta. General Subjects·Hans Henning BrewitzDiana Imhof
Oct 5, 2017·Immunopharmacology and Immunotoxicology·Yubin XuDeqiang Dou
Jul 15, 2020·Biotechnology and Bioengineering·Eun Young KimSong Yub Shin
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin DavidoPierre de Truchis
May 19, 2017·Antimicrobial Resistance and Infection Control·James A AyukekbongAndrew N Atabe
Apr 13, 2018·Frontiers in Pharmacology·Anja PfalzgraffGünther Weindl
Mar 8, 2020·Biochimica Et Biophysica Acta. Biomembranes·Sebastian FingerAlfred Blume
Aug 16, 2017·Journal of Chemical Information and Modeling·Julia Nogueira VarelaVikramaditya G Yadav

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