PMID: 8453714Mar 1, 1993Paper

Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase

Carcinogenesis
Y YokoyamaK Sato

Abstract

While glutathione S-transferase P form (GST-P), a reliable marker for preneoplastic lesions induced by mutagenic hepatocarcinogens, is generally not expressed in rat liver foci, hyperplastic nodules and hepatomas induced by peroxisome proliferators (PPs), such lesions can be detected due to their peroxisomal enzyme-negative nature. For comparative purposes we examined the inducibility of enoyl CoA hydratase (ECH), a key peroxisomal enzyme, in rat hepatic preneoplastic lesions induced by mutagenic carcinogens. Clofibrate (CF) was therefore administered for 2 or 4 weeks following performance of the Solt-Farber protocol using diethylnitrosamine and 2-acetylaminofluorene. Immunohistochemical examination revealed no or only very weak expression of ECH within the induced foci in clear contrast to the strong staining of surrounding parenchyma. ECH expression was thus diametrically opposed to that of GST-P which was found only in foci. Although ECH was completely lacking in GST-P-strongly positive foci, it was expressed in GST-P-negative hepatocytes inside some foci otherwise positive for GST-P. CF administration resulted in a significant decrease in the numbers and areas of foci exhibiting strongly positive or positive GST-P staining;...Continue Reading

Citations

Sep 9, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jihei NishimuraKunitoshi Mitsumori
Mar 22, 2002·The Lancet Oncology·E LaconiE Farber
Jan 24, 1998·Japanese Journal of Cancer Research : Gann·H NakanoS Tsuchida
Oct 31, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·James E KlaunigRichard Billington
Apr 14, 2007·Molecular Cancer Therapeutics·Yoshihito YokoyamaHideki Mizunuma

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