Lack of pharmacokinetic interaction between 5-fluorouracil and oxaliplatin

Clinical Pharmacology and Therapeutics
Simon P JoelM Seymour

Abstract

Our objective was to investigate the influence of oxaliplatin on the pharmacokinetics of 5-fluorouracil (5FU) administered in a bolus plus infusional regimen. All patients had advanced/metastatic colorectal cancer. In study 1, 19 patients were studied after bolus (400 mg/m(2)) plus a 22-hour infusion (600 mg/m(2)) of 5FU/leucovorin in the standard de Gramont regimen or the same regimen with oxaliplatin (85 mg/m(2)) given before 5FU. In study 2, 12 patients were studied for 2 treatment cycles, with 5FU given in a modified de Gramont regimen comprising bolus (400 mg/m(2)) plus a 46-hour infusion (2400 mg/m(2)) of 5FU. During 1 of these cycles, oxaliplatin (85 mg/m(2)) was given before 5FU. The coadministration of oxaliplatin did not significantly alter 5FU area under the plasma concentration-time curve from 0 to 1 hour, area under the plasma concentration-time curve from time 0 to the last time point, or steady-state concentration in either the de Gramont (11.6 +/- 3.8 mg/L x h(-1), 14.9 +/- 4.2 mg x h/L, and 0.17 +/- 0.06 mg/L, respectively, for 5FU alone versus 9.4 +/- 2.6 mg/L x h(-1), 13.3 +/- 2.3 mg x h/L, and 0.16 +/- 0.04, respectively, for 5FU plus oxaliplatin) or modified de Gramont regimens (13.4 +/- 2.2 mg x h/L, 35.4 ...Continue Reading

Citations

Jan 9, 2009·Investigational New Drugs·D MulkerinG Wilding
Dec 14, 2011·Expert Opinion on Pharmacotherapy·Alexander Stein, Dirk Arnold
May 25, 2006·Clinical Pharmacokinetics·Su-arpa PloylearmsaengAlexander Jetter
May 26, 2005·Current Treatment Options in Gastroenterology·Everardo D Saad, Paulo M Hoff
Jul 10, 2008·Clinical Pharmacokinetics·Anthe S ZandvlietAlwin D R Huitema
Dec 22, 2004·Drugs·Susan J KeamDavid P Figgitt
Jan 28, 2020·PLoS Computational Biology·Roger J W HillAnnabelle Ballesta
Nov 18, 2018·Cancer Chemotherapy and Pharmacology·Laure DeymeFlorence Gattacceca
Oct 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jordan BerlinJennifer A Low
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wandena S Siegel-LakhaiJan H M Schellens

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