Lack of pharmacokinetic interaction between lamotrigine and olanzapine in healthy volunteers

Pharmacotherapy
Michael W JannVicky Spratlin

Abstract

To investigate the potential drug-drug interaction between lamotrigine, an antiepileptic agent used to treat bipolar disorders, and olanzapine, an atypical antipsychotic drug also used to treat bipolar disorders, both of which are metabolized by the uridine diphosphate glucuronosyltransferase system. Prospective cohort study. University center for clinical research. Fourteen nonsmoking, healthy volunteers. Subjects received lamotrigine 25 mg/day for 5 days, then 50 mg/day for 10 days to achieve steady-state concentrations. On day 15, blood samples were obtained before and 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 hours after the dose. Lamotrigine 50 mg/day was then given for an additional 3 days. On the next day, lamotrigine 50 mg and olanzapine 5 mg were coadministered. Blood samples were obtained at the same times as before and at 48, 72, and 96 hours after dosing. Blood samples were assayed for lamotrigine and olanzapine concentrations by means of high-performance liquid chromatography. Olanzapine did not significantly affect lamotrigine disposition, as we observed no differences in the area under the concentration-time curve from 0-24 hours or in lamotrigine plasma concentrations at baseline or at 24 hours. For lamotrigine, the...Continue Reading

References

Nov 1, 1987·Clinical Pharmacology and Therapeutics·A F CohenA W Peck
Jun 9, 1995·Journal of Chromatography. B, Biomedical Applications·J T CatlowS P Swanson
Dec 1, 1993·Clinical Pharmacokinetics·B Rambeck, P Wolf
Aug 1, 1996·Clinical Pharmacology and Therapeutics·G D AndersonA T Dren
Jul 10, 1998·Journal of Pharmaceutical and Biomedical Analysis·K M MatarA Tekle
Oct 8, 1999·Clinical Pharmacokinetics·J T CallaghanC M Beasley
Oct 11, 2001·Journal of Clinical Psychopharmacology·H L ListonC L DeVane
Feb 2, 2002·Clinical Pharmacology and Therapeutics·John S MarkowitzS Craig Risch
Apr 30, 2002·The Annals of Pharmacotherapy·Stephen C Hurley
May 15, 2002·The Journal of Clinical Psychiatry·Trisha SuppesUNKNOWN Texas Consensus Conference Panel on Medication Treatment of Bipolar Disorder
Jun 4, 2002·The American Journal of Psychiatry·Mauricio TohenGary A Tollefson
Dec 10, 2002·The Journal of Clinical Psychiatry·David M Labiner
Feb 4, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Brian Burchell
Mar 18, 2003·Journal of Clinical Psychopharmacology·Robert W BakerGary D Tollefson
Mar 20, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kara Lee ShirleyMichael W Jann
Apr 23, 2003·Biological Psychiatry·Paul E KeckSusan L McElroy
May 27, 2003·Therapeutic Drug Monitoring·Svein I JohannessenPhilip N Patsalos
Nov 12, 2003·Archives of General Psychiatry·Mauricio TohenAlan Breier

❮ Previous
Next ❯

Citations

Oct 31, 2013·CNS Drugs·William Klugh KennedyEric C Kutscher
Feb 16, 2012·Expert Opinion on Drug Metabolism & Toxicology·Jose de LeonEdoardo Spina
Feb 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edoardo SpinaJose de Leon
Mar 9, 2010·Thérapie·Danièle Bentué-FerrerUNKNOWN le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique
Jun 17, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sheila BottsJose de Leon
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Edoardo Spina, Jose de Leon
Nov 22, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Todd M ConnerTao Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here