Lack of plasma lipid peroxidation during LDL-apheresis by heparin-induced extracorporeal LDL-precipitation

European Journal of Clinical Investigation
E WielandP Schuff-Werner

Abstract

The heparin-induced extracorporeal precipitation of low density lipoproteins (HELP) is a well established clinical apheresis procedure to markedly reduce cholesterol levels. The biocompatibility of this filter system was investigated by the determination of lipid peroxidation products. Both lipid hydroperoxides and thiobarbituric acid reactive substances (TBARS) were determined before, during and after 38 aphereses in 21 patients undergoing regular HELP treatment. Although HELP patients had significantly elevated TBARS compared to 93 healthy controls (3.13 +/- 0.64 vs. 1.66 +/- 0.50 mumol L-1; P < 0.01), no significant differences were observed compared to either 104 patients suffering from angiographically confirmed coronary heart disease (3.42 +/- 0.81 mumol L-1; P > 0.05 vs. HELP patients) or 38 aged-matched hyperlipidaemic patients (3.30 +/- 0.75 mumol L-1; P > 0.05 vs. HELP patients), neither of which were included in the HELP programme. No lipid hydroperoxides were detected in the plasma of HELP patients either before or after the extracorporeal treatment. After the LDL-apheresis TBARS were significantly decreased (2.60 +/- 0.52 mumol L-1) compared to the values before the treatment (P < 0.01). There was no evidence for t...Continue Reading

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Citations

Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·K KostnerK Derfler
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·R BaricchiA Tomasi
Jan 29, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Volker SchettlerEberhard Wieland
Apr 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Chiang-Ting ChienSu-Ming Hsu
Mar 7, 2019·Clinical Research in Cardiology Supplements·V J J SchettlerUNKNOWN Scientific Board of GLAR for the German Apheresis Working Group
Jul 31, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·V SchettlerE Wieland

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