May 26, 1995

Lack of platelet-activating factor release on acute myocardial ischemia in the isolated interventricular septum of rabbit heart

European Journal of Pharmacology
P SalinasS Barrigon


The effects of platelet-activating factor (PAF) on myocardial injury after 1 h global ischemia-30 min reperfusion were investigated in isolated arterially perfused interventricular septum of rabbit heart. PAF did not significantly affect developed tension, +/- dT/dtmax, resting tension and the times of active state in non-ischemic septa. The recovery of developed tension was significantly reduced by PAF (100 nM), after an ischemia-reperfusion challenge, from the control value of 20.9 +/- 3.5% to 10.5 +/- 1.8%, without a change in the resting tension (15.7 +/- 2.8 vs. 15.6 +/- 1.3 g). BN 52021 (20 microM), alone did not modify either parameter of ischemic damage, but antagonized the aggravating effect of PAF. Evidence of PAF activity was not found in any of the samples of the effluent perfusate obtained from ischemic control experiments. On the basis of the present results, we suggest a direct role for PAF in aggravating the myocardial damage induced by ischemia, and discard heart cells as the source of PAF in this state.

  • References17
  • Citations2


Mentioned in this Paper

Myocardial Contraction
Left Ventricular Structure
Ginkgolide B, (1beta)-isomer
Myocardial Ischemia
Acute Disease

Related Feeds


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.