Lack of pupil reflex and loss of consciousness predict 30-day neurological sequelae in patients with carbon monoxide poisoning

PloS One
Jian-Fang ZouChien-Cheng Huang

Abstract

Predicting the neurological sequelae of carbon monoxide poisoning (COP) has not been well studied. We investigated the independent predictors of neurological sequelae in patients with COP and combined these predictors to predict the prognosis. This study was conducted at four hospitals in Shandong Province, China. Data were retrospectively collected from 258 patients with COP between November 1990 and October 2011. Thirty-day neurological sequelae were the primary endpoints. A lack of pupil reflex and a loss of consciousness appear to be independent predictors for neurological sequelae in patients with COP. The presence of either one had a sensitivity of 77.0% (95% confidence interval [CI]: 69.3-83.2), a specificity of 47.1% (95% CI: 38.3-56.0), positive predictive value (PPV) of 62.9% (95% CI: 55.2-70.1), and a negative predictive value (NPV) of 63.6% (95% CI: 52.6-73.4). With both predictors present, the sensitivity was 11.5% (95% CI: 6.9 to 18.3), the specificity was 99.2 (95% CI: 94.7-100.0), the PPV was 94.1% (95% CI: 69.2-99.7), and the NPV was 49.0% (95% CI: 42.5-55.5). The risk for neurological sequelae apparently increased with the number of independent predictors. In patients with both predictors, the risk for neurolo...Continue Reading

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Citations

May 26, 2016·Revista clínica española·P GodoyM Alsedà
Jan 23, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Kemal TekinPelin Yilmazbas
Nov 16, 2019·Cardiovascular Toxicology·Chien-Cheng HuangHow-Ran Guo
Oct 4, 2017·Oncotarget·Chien-Cheng HuangHow-Ran Guo
Jul 15, 2017·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Chien-Cheng HuangHow-Ran Guo
Oct 17, 2018·Journal of Clinical Medicine·Chien-Cheng HuangHow-Ran Guo

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