Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions

International Journal of Cardiology
Friedhelm KuetheHans R Figulla

Abstract

Experimental and preliminary clinical data suggest that transplantation of autologous bone marrow cells (BMC) may contribute to regeneration of the myocardium after acute myocardial infarction. This approach should be tested in patients with large infarctions in whom a positive effect would be most beneficial. After successful recanalization within 5.9 +/- 2.5 h and stent implantation in five patients with a large acute anterior myocardial infarction (AMI), the patients received autologous mononuclear BMCs via a balloon catheter placed into the left anterior descending artery 6.3 +/- 0.4 days after revascularization. At 3-month follow-up, no improvement was observed for left ventricular ejection fraction, regional wall motion in the infarcted zone, contractility index measured via dobutamine stress echocardiography, coronary blood flow reserve and maximal oxygen uptake, respectively. After further follow-up of 12 months, again no change of the left ventricular ejection fraction could be detected. Intracoronary transplantation of autologous mononuclear BMCs did not improve cardiac function in our patients with large anterior myocardial infarctions after 3 and 12 months.

Citations

Jun 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·L BindslevJ Kastrup
Oct 21, 2005·Basic Research in Cardiology·H C OttD A Taylor
Oct 21, 2005·Basic Research in Cardiology·Jeffrey M Zimmet, Joshua M Hare
Dec 31, 2005·Basic Research in Cardiology·Mihail Hristov, Christian Weber
Aug 29, 2006·Heart Failure Reviews·E LeontiadisD V Cokkinos
Mar 28, 2007·Current Heart Failure Reports·Doris A Taylor, Andrey G Zenovich
Nov 3, 2006·Current Treatment Options in Cardiovascular Medicine·Hüseyin InceChristoph A Nienaber
Jun 1, 2008·Journal of Cardiovascular Translational Research·Cindy M Martin
Dec 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr MusialekWieslawa Tracz
Apr 20, 2005·International Journal of Cardiology·Friedhelm KuetheHans R Figulla
Aug 16, 2005·Lancet·A VatsJ M Polak
Mar 7, 2009·Stem Cells and Development·Elske J SchabortCarola U Niesler
Dec 25, 2008·Regenerative Medicine·Chia Yeo, Anthony Mathur
Jan 31, 2012·Imaging in Medicine·Yingli FuDara L Kraitchman
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Andrey G Zenovich, Doris A Taylor
Feb 15, 2011·Annual Review of Physiology·Jennifer A Dixon, Francis G Spinale
Jan 11, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nicole AzeneDara L Kraitchman
Jul 31, 2010·Expert Review of Cardiovascular Therapy·Thomas J Povsic, Christopher M O'Connor
Aug 22, 2006·Expert Opinion on Biological Therapy·Harald C Ott, Doris A Taylor
Nov 4, 2011·Journal of Drug Targeting·Thomas J KeanJames E Dennis
Apr 14, 2006·Expert Opinion on Biological Therapy·Thomas J Povsic, Eric D Peterson
Sep 14, 2007·Annals of Medicine·Pedro L SánchezFrancisco Fernández-Avilés
Nov 10, 2005·Annals of Medicine·Linda W Van LaakeChristine L Mummery
Dec 21, 2006·Archives of Physiology and Biochemistry·Alexandrina Burlacu
Jan 9, 2013·Cytotherapy·Winston ShimTian Hai Koh
Aug 14, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Jason M DuranJon C George
Dec 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Jon C George
Feb 26, 2009·Cytotherapy·Julie A MundJamie Case
Aug 30, 2008·Journal of Molecular and Cellular Cardiology·Kentaro JujoDouglas W Losordo
Jun 19, 2007·Trends in Molecular Medicine·Claudio NapoliLouis J Ignarro
Feb 13, 2007·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Haakon K GrøgaardArnfinn Ilebekk
Dec 14, 2004·Congestive Heart Failure·Loren E WoldRobert A Kloner
May 20, 2008·Echocardiography·Roman PanovskyMilan Navratil
Jul 12, 2008·Journal of Tissue Engineering and Regenerative Medicine·Pawanbir Singh, David J Williams
Feb 22, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexander HirschFelix Zijlstra
Jun 19, 2012·British Journal of Clinical Pharmacology·Daniel M ReedJane A Mitchell
May 28, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Faisal SharifMarc Vanderheyden

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