Lack of renal 11 beta-hydroxysteroid dehydrogenase type 2 at birth, a targeted temporal window for neonatal glucocorticoid action in human and mice.

PloS One
Laetitia MartinerieMarc Lombès

Abstract

Glucocorticoid hormones play a major role in fetal organ maturation. Yet, excessive glucocorticoid exposure in utero can result in a variety of detrimental effects, such as growth retardation and increased susceptibility to the development of hypertension. To protect the fetus, maternal glucocorticoids are metabolized into inactive compounds by placental 11beta-hydroxysteroid dehydrogenase type2 (11βHSD2). This enzyme is also expressed in the kidney, where it prevents illicit occupation of the mineralocorticoid receptor by glucocorticoids. We investigated the role of renal 11βHSD2 in the control of neonatal glucocorticoid metabolism in the human and mouse. Cortisol (F) and cortisone (E) concentrations were measured in maternal plasma, umbilical cord blood and human newborn urine using HPLC. 11βHSD2 activity was indirectly assessed by comparing the F/E ratio between maternal and neonatal plasma (placental activity) and between plasma and urine in newborns (renal activity). Direct measurement of renal 11βHSD2 activity was subsequently evaluated in mice at various developmental stages. Renal 11βHSD2 mRNA and protein expression were analyzed by quantitative RT-PCR and immunohistochemistry during the perinatal period in both species...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·S UlickM I New
Jul 1, 1988·The Journal of Clinical Investigation·P M StewartC R Edwards
Feb 6, 1993·Lancet·R BenediktssonC R Edwards
Mar 28, 1997·Molecular and Cellular Endocrinology·J CondonP M Stewart
Jun 1, 1997·Endocrine Reviews·S Mesiano, R B Jaffe
Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·J CondonP M Stewart
Apr 13, 1999·The Journal of Clinical Endocrinology and Metabolism·G HirasawaZ S Krozowski
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·M DodicM Wintour
Apr 12, 2000·Kidney International·N Farman, B Bocchi
Feb 24, 2001·American Journal of Physiology. Renal Physiology·N Farman, M E Rafestin-Oblin
Apr 11, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S HundertmarkJ R Seckl
Apr 25, 2001·Kidney International·L A OrtizM Baum
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Omar A ItaniChristie P Thomas
Oct 4, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·Caroline E Bertram, Mark A Hanson
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Eero KajantieSture Andersson
Feb 8, 2003·Hypertension·Luis A OrtizMichel Baum
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Jonathan P van BeekKaiping Yang
Aug 5, 2005·The Journal of Endocrinology·Nicole Draper, Paul M Stewart
Oct 6, 2005·The Journal of Steroid Biochemistry and Molecular Biology·J R Pasqualini
Jul 21, 2006·The Cochrane Database of Systematic Reviews·D Roberts, S Dalziel
Feb 23, 2007·Journal of the American Society of Nephrology : JASN·Atanas G AtanasovAlex Odermatt
Jan 5, 2008·Nuclear Receptor Signaling·Say ViengchareunMarc Lombès
Aug 30, 2008·BMC Medicine·Susanna Y HuhMatthew W Gillman
Oct 3, 2008·Pediatrics·Susan W AucottUNKNOWN PROPHET Study Group
Oct 11, 2008·Endocrinology·Caitlin S WyrwollMegan C Holmes
Jun 23, 2009·Pediatric Research·Laetitia MartinerieMarc Lombès
Oct 2, 2009·American Journal of Physiology. Renal Physiology·Michel Baum

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Citations

Feb 11, 2015·Current Opinion in Pharmacology·Robert W Hunter, Matthew A Bailey
Aug 1, 2013·Physiological Reviews·Karen ChapmanJonathan Seckl
Feb 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Samantha L RogersJeremy W Tomlinson
Jun 3, 2021·International Journal of Molecular Sciences·Margaux LaulhéLaetitia Martinerie

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Methods Mentioned

BETA
PCR
protein assay

Software Mentioned

Prism
GraphPad

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